Liquid Biopsy for Early Detection of Colorectal Cancer

This study is looking for a better way to find colorectal cancer (CRC) early. Researchers are testing a "liquid biopsy" called a cf-circRNA assay. This test looks for special circular RNAs (cf-circRNAs) in your blood (plasma or serum) that might show if you have CRC. You could join if you are an adult (18 or older) with confirmed Stage I-III colorectal cancer and have blood samples available from before your treatment. The main goal is to see how well this test can find CRC (its "sensitivity"). This is an observational study, meaning researchers will collect information without giving new treatments, and it plans to include 600 participants. The study status is currently unclear.

Study design
This is an observational study planning to enroll 600 participants to test a diagnostic method.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, sensitivity, is measured through study completion, an average of 1 year.

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NCT07224789

Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA

Recruiting
Not specifiedAges 18+Observational
City of Hope Medical Center
~600 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:cf-circRNA assay

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity
Measured over Through study completion, an average of 1 year
Colorectal Cancer
1 sites across 1 states
California1
  • Ajay Goel, PhD · PRINCIPAL_INVESTIGATOR · City of Hope Medical Center

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Eligibility criteria

Inclusion

Adults (≥18 years old)
Histologically confirmed colorectal cancer (Stage I-III)
Availability of pre-treatment plasma samples
Written informed consent provided

Exclusion

History of other active malignancies within the past 5 years
Poor sample quality or hemolysis
Inability to provide informed consent
  • SensitivityThrough study completion, an average of 1 year

    Proportion of early-stage (Stage I-II) colorectal cancer patients correctly identified as positive by the circRNA-based diagnostic model.