Home Intravenous Fluid Infusion After Radical Cystectomy for Bladder Cancer

This study is for people with bladder cancer, including muscle invasive bladder cancer, who are having surgery called a radical cystectomy. This surgery removes the bladder and is the standard treatment for muscle invasive bladder cancer. After this surgery, some people experience complications like dehydration. This study wants to find out if giving intravenous fluids (IVF) at home after surgery can help prevent these complications and reduce hospital readmissions. You would be randomly assigned to either receive 1 liter of lactated ringers or normal saline through an IV three times a week for four weeks at home with a nurse, or to receive standard care without these home IV fluids. The main goal is to see how many people are readmitted to the hospital within 90 days after surgery. To join, you must be over 18, have confirmed bladder cancer, and be planning to have a radical cystectomy. The study's current status is unclear, and it plans to enroll 130 participants.

Study design
This is an interventional study that will randomly assign 130 participants to one of two groups. One group will receive home intravenous fluids, and the other will receive standard care.
What's involved
If you are in the home IVF group, you will receive 1 liter of intravenous fluids three times a week for four weeks with a home nurse. If you do not have existing vascular access, you will not receive a midline catheter.
Compensation
Not stated in the trial record.
Follow-up
The study will measure hospital readmission rates for up to 90 days after your surgery.

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NCT07225205

Home Intravenous Fluid Infusion After Undergoing Radical Cystectomy

Recruiting
NAAges 18+InterventionalPrevention
Johns Hopkins University
~130 participants
Updated 2025-11-20 on ClinicalTrials.gov
What's tested:Intravenous fluidsERAS

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants with 90-day Hospital Readmission
Measured over From date of surgery up to 90-days postoperatively
Bladder Cancer
Muscle Invasive Bladder Cancer (MIBC)
Muscle Invasive Bladder Cancer Urothelial Carcinoma
Cystectomy
2 sites across 1 states
Maryland2
  • Max Kates, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins School of Medicine

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Eligibility criteria

Inclusion

Adult patients greater than 18 years of age and older
Confirmed urothelial carcinoma on pathology, including muscle invasive, non-muscle invasive, and variant histology
Patient electing to undergo radical cystectomy with bilateral pelvic lymphadenectomy after counseling with a urologic oncologist.

Exclusion

Patients undergoing radical cystectomy for benign indications (e.g. chronic bladder pain, fistulas, severe lower urinary tract symptoms)
Patients undergoing radical cystectomy for a non-bladder primary malignancy (e.g. rectal, colon, uterine cancers).
Patients with extensive locally advanced disease necessitating a pelvic exenteration
Contraindication to receiving home IVF therapy (i.e. pre-existing cardiac, renal, hepatic dysfunction)
Unwilling or unable to participate in 30 and 90 day follow-up phone calls.
  • Percentage of participants with 90-day Hospital ReadmissionFrom date of surgery up to 90-days postoperatively

    The primary outcome will be 90-day hospital readmissions that are unplanned, including admissions for observation