Back to search results

Recovery of Physical Function After Critical Illness In Older Adults

This observational study is looking at how older adults recover muscle and physical abilities after a critical illness like sepsis or acute lung injury (ALI). Researchers want to understand why some people regain their strength and others don't. They will measure your muscle strength and how well you can do daily activities over two years. This study is for adults aged 40 to 99 who were in the ICU for at least 72 hours and could walk before their illness. There are no specific interventions (treatments) being tested; instead, researchers are observing recovery. The goal is to understand the long-term recovery process for 150 participants.

Study design
This is an observational study involving 150 participants. It is not testing a specific drug or treatment.
What's involved
You would participate in testing at the time of hospital discharge, and then again at 3, 6, 12, and 24 months after discharge. A small group of participants will also have muscle biopsies.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 24 months after hospital discharge.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07225257

Recovery of Physical Function After Critical Illness In Older Adults

Recruiting
Not specifiedAges 18–99Observational
University of Kentucky
~150 participants
Updated 2026-05-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Muscle Strength measured by Chair Rise Test
Measured over Baseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.
+1 more outcome measured

Conditions

Sepsis
Acute Lung Injury(ALI)

Explore related trials

Acute Lung InjuryAcute Respiratory FailureICU-Acquired Muscle WeaknessSepticemia

Where it's being run

1 sites across 1 states
Kentucky1

Study leadership

  • Kirby P Mayer, DPT, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Kentucky

Who to contact

Doug Long, MS
[email protected]
859-218-0596
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

adult patients (≥40 years of age)
patients who have survived an ICU admission of at least 72 hours
diagnosis of acute lung injury or sepsis are eligible.

Exclusion

individuals who were not ambulatory prior to ICU admission,
not expected to survive at least 6 months,
have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing,
have a pre-existing geriatric syndrome that were confound recovery trajectory

What this trial measures

  • Muscle Strength measured by Chair Rise TestBaseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.

    Performance on 5x sit to stand test will be the primary outcome measure representing lower extremity muscle strength ; measured as time in seconds to complete 5 repetitive sit-stands.

  • Functional CapacityBaseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.

    The 6-minute walk test (6MWT), which measures the distance a participant can walk in six minutes and serves as an indicator of cardiopulmonary function, will be used as a primary outcome.