Low Intensity Focused Ultrasound for Autism Spectrum Disorder

This study is looking at a treatment called Low Intensity Focused Ultrasound (LIFU) for people with Autism Spectrum Disorder (ASD). LIFU uses sound waves to target a specific area of the brain called the thalamus. All participants in this study will receive active LIFU. Researchers want to see if LIFU is safe and if it can help with social responsiveness, which will be measured using a questionnaire called the Social Responsiveness Scale, Second Edition (SRS-2). You might be able to join if you are 13-25 years old, have an ASD diagnosis, and a Full Scale IQ over 70. The study is planning to enroll 20 participants, but its current recruitment status is unclear.

Study design
This is an open-label study, meaning everyone knows they are receiving the active LIFU treatment. It plans to enroll 20 participants.
What's involved
You would receive LIFU stimulation and have your social responsiveness measured at the beginning, right after the last treatment, and one month later.
Compensation
Not stated in the trial record.
Follow-up
Your social responsiveness will be measured up to one month after your last treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07225322

Low Intensity Focused Ultrasound in ASD

Not Yet Recruiting
PHASE1Ages 13–25InterventionalTreatment
Medical University of South Carolina
~20 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Active LIFU

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Social Responsiveness Scale, Second Edition (SRS-2)
Measured over Baseline (Visit 1) to post-stimulation (Visit 7, within 1 week of last stimulation; Visit 8, within 1 month of last stimulation)
Autism Spectrum Disorder

NCT07225322

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • MUSC Brain Stimulation Offices

    Charleston, South Carolinastudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Kevin Caulfield, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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Eligibility criteria

Inclusion

Age 13-25
Diagnosis of ASD (DSM-5)
Full Scale IQ \> 70
Verbal communication
Stable medication for ≥1 month
Ability to consent or assent with guardian consent

Exclusion

MRI or LIFU contraindications
Recent investigational drug/device use
Neurological illness (e.g., epilepsy, TBI)
Substance use disorder
Sensory/motor impairments preventing task completion
  • Social Responsiveness Scale, Second Edition (SRS-2)Baseline (Visit 1) to post-stimulation (Visit 7, within 1 week of last stimulation; Visit 8, within 1 month of last stimulation)