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Virtual Reality Training for Mild Cognitive Impairment

This study is testing a new way to help people with Mild Cognitive Impairment (MCI) improve their navigation skills. You would train in a full-immersive virtual reality (VR) environment, learning to find your way through a maze. The researchers want to see if this VR training can help you improve your maze completion time. They also want to understand how your brain activity changes during this training. To join, you need to be 65 or older, have amnestic MCI, speak English, and be able to walk for 10 minutes without help. The study is currently unclear on its recruitment status and plans to enroll 30 participants.

Study design
This is a single-arm study, meaning all 30 participants will receive the virtual reality training. It is not specified if participants or researchers will know who is receiving the intervention (open-label or blinded).
What's involved
You would participate in twenty-four 50-minute training sessions over a 4-month period. During these sessions, you will walk in an open space while wearing VR goggles.
Compensation
Not stated in the trial record.
Follow-up
Your maze completion time will be measured at 4 months after the start of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07225400

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

Recruiting
NAAges 65+Interventional
Albert Einstein College of Medicine
~30 participants
Updated 2026-09-11 on ClinicalTrials.gov
What's tested:Spatial Navigation training

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Immediate Maze Time (IMT)
Measured over Change from baseline to post-intervention at 4 months

Conditions

Mild Cognitive Impairment (MCI)

Explore related trials

Mild cognitive disorder

NCT07225400

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Albert Einstein College of Medicine

    The Bronx, New Yorkstudy coordinator listed

    Recruiting

  • Columbia University Irving Medical Center

    Manhattan, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Pierfilippo De Sanctis, PhD · PRINCIPAL_INVESTIGATOR · Albert Einstein College of Medicine

Who to contact

Pierfilippo De Sanctis, PhD
[email protected]
718-862-1828
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Age 65 and older with amnestic mild cognitive impairment (aMCI);
Can speak English;
Agrees to MoBI recording;
Normal or corrected-to-normal vision/audition;
Able to walk unassisted for 10 minutes;
Plan to be in the area for next year

Exclusion

Dementia (Memory Impairment/AD8 screen);
Medical conditions that affect participation such as vertigo and neck pain;
Hospitalization in the past six months or plans for surgery affecting participation in the next four months;
Mobility limitations solely due to musculoskeletal limitation or pain;
Terminal illness with life expectancy less than 12 months;
Presence of clinical disorders that overtly alter attention like delirium;
Active psychoses or psychiatric symptoms;
Living in nursing home;
Participation in intervention trial;
Standard contraindications to EEG including seizure medication, epilepsy, stroke, traumatic brain injury;
Pregnant women

What this trial measures

  • Change in Immediate Maze Time (IMT)Change from baseline to post-intervention at 4 months

    Change in immediate maze time will be assessed as a Behavioral marker of change and determined using the floor maze test (FMT), which combines navigation with walking. Participants will be positioned at the entry point of the FMT and instructed to find their way to the exit point of the FMT. A fixed 15-second planning period will be given to plan the route. The time elapsed from the end of the planning period to successful exit (i.e., IMT), in seconds, will be recorded. Paired t-tests will be used to compare the Floor Maze Test time between baseline and post intervention.