HOLIDAY Study: Hormonal Optimization for Fertility Preservation
The HOLIDAY study is looking at how the timing of stopping birth control pills (Combined Hormonal Contraceptives or CHC) affects egg freezing (oocyte cryopreservation). Researchers want to see if taking a 2-month break from CHC before egg freezing leads to better results compared to starting the process right away without a break. This study is for women aged 18 to 40 who are planning to freeze their eggs. To be successful, the study will measure the rate at which eggs mature and the total number of eggs retrieved during the procedure. The study is currently unclear on its recruitment status and plans to enroll 394 participants.
- Study design
- This is a multi-center, randomized study with two groups. Participants will be assigned by chance to either stop birth control for two months or start egg freezing immediately.
- What's involved
- Participants in one group will be asked to stop their combined hormonal contraceptives for 2 months before their planned egg freezing procedure.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcomes, oocyte maturation rate and number of oocytes retrieved, are measured during the oocyte retrieval procedure.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
At a glance
Conditions
Where it's being run
3 sites across 3 statesWho to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Oocyte maturation rateDuring oocyte retrieval
Median number of percentage of vitrified MII oocytes yielded per cycle
- Number of oocytes retrievedDuring oocyte retrieval
The median number of cumulus-oocyte complexes (COC) retrieved during oocyte retrieval