HOLIDAY Study: Hormonal Optimization for Fertility Preservation

The HOLIDAY study is looking at how the timing of stopping birth control pills (Combined Hormonal Contraceptives or CHC) affects egg freezing (oocyte cryopreservation). Researchers want to see if taking a 2-month break from CHC before egg freezing leads to better results compared to starting the process right away without a break. This study is for women aged 18 to 40 who are planning to freeze their eggs. To be successful, the study will measure the rate at which eggs mature and the total number of eggs retrieved during the procedure. The study is currently unclear on its recruitment status and plans to enroll 394 participants.

Study design
This is a multi-center, randomized study with two groups. Participants will be assigned by chance to either stop birth control for two months or start egg freezing immediately.
What's involved
Participants in one group will be asked to stop their combined hormonal contraceptives for 2 months before their planned egg freezing procedure.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, oocyte maturation rate and number of oocytes retrieved, are measured during the oocyte retrieval procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07225660

Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)

Recruiting
NAAges 18–40InterventionalTreatment
Shady Grove Fertility Reproductive Science Center
~394 participants
Updated 2026-03-02 on ClinicalTrials.gov
What's tested:OCP pause

At a glance

Recruiting sites
2 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Oocyte maturation rate
Measured over During oocyte retrieval
+1 more outcome measured
Fertility Preservation
3 sites across 3 states
Connecticut1
Maryland1
New York1
Tasha Newsome, Clinical Research Supervisor
Email the study team

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  • Oocyte maturation rateDuring oocyte retrieval

    Median number of percentage of vitrified MII oocytes yielded per cycle

  • Number of oocytes retrievedDuring oocyte retrieval

    The median number of cumulus-oocyte complexes (COC) retrieved during oocyte retrieval