Bridging Antiplatelet Therapy With Cangrelor 2 Study for Coronary Artery Disease
This study is looking at how to best use a medication called cangrelor to prevent blood clots in people with coronary artery disease (CAD). Cangrelor is given as a bridge when patients need to temporarily stop other anti-clotting medicines before a heart procedure. The study will test if adjusting the dose of cangrelor based on your platelet reactivity (how sticky your platelets are) works better than a standard dose. We want to see if this personalized approach can help more patients reach an "optimal platelet reactivity" level, which is a specific range (PRU levels between 85 and 208). You might be able to join if you are at least 18 years old, have CAD, and are already receiving cangrelor before a heart procedure. The study aims to enroll 50 participants and is currently unclear on its recruitment status.
- Study design
- This is a single-arm, open-label study involving 50 participants. It is not specified if there are different phases of the study.
- What's involved
- If you join, you will have blood samples taken to measure your platelet reactivity. Based on these results, your cangrelor dose may be adjusted, and more blood samples will be taken 2 to 12 hours later.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your platelet reactivity will be assessed 2 to 12 hours after any dose adjustments.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The Bridging Antiplatelet Therapy With Cangrelor 2 Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Dominick J Angiolillo, MD, PhD · STUDY_CHAIR · University of Florida College of Medicine - Jacksonville
- Luis Ortegra-Paz, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Florida College of Medicine - Jacksonville
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Optimal platelet reactivity2-12 hours
PRU levels between 85 and 208, when using a (PFT)-guided titration of cangrelor infusion rate (cangrelor titration) compared to 0.75 mcg/kg/min (standard-dose infusion) for bridging