Methadone for Pain After Total Knee Replacement
This study is looking at whether a medication called methadone hydrochloride, given during surgery, can help reduce pain and the need for other pain medications after a total knee replacement (arthroplasty). You might be able to join if you are between 18 and 75 years old and are having an elective total knee replacement with a specific type of spinal anesthesia. The main goal is to see how much pain patients report in the recovery room up to 24 hours after surgery. The study is currently recruiting 162 participants, but its overall status is unclear.
- Study design
- This is a randomized, double-blind controlled trial, meaning participants are randomly assigned to groups and neither you nor your doctors will know if you received methadone. It plans to enroll 162 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your pain will be measured in the recovery unit for up to 24 hours after your surgery ends.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Methadone in TKA for Post-op Pain and Opioid Reduction
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- William Barrett, M.D. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Patient reported pain in the recovery unit after surgeryup to 24 hours after surgery ends
Patient reported pain on a Visual Analog Scale (VAS) from 0-100mm at approximately 30-60 minutes after arriving to the recovery unit after surgery. A lower pain score means a better outcome.