A Study of MEN2501 for Platinum-Resistant Ovarian Cancer

This study is testing a new oral tablet called MEN2501 in people with platinum-resistant ovarian cancer. This means your cancer has not responded well to platinum-based chemotherapy. The study aims to find a safe and effective dose of MEN2501. Researchers will look at how safe MEN2501 is and how well your body handles it. They will also see if it can shrink tumors. You may be able to join if you are an adult woman with high-grade serous ovarian, primary peritoneal, or fallopian tube cancer that is platinum-resistant. The study is currently not clear on its recruitment status.

Study design
This is a first-in-human, open-label (meaning you and your doctors will know what treatment you are receiving) study. It will involve about 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will measure the recommended dose for up to approximately 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07226427

A First-in-Human Study of MEN2501 in Participants With Platinum-Resistant Ovarian Cancer

Recruiting
PHASE1Ages 18+InterventionalTreatment
Stemline Therapeutics, Inc.
~100 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:MEN2501

At a glance

Recruiting sites
15 of 15 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Part A Only: Number of Participants with Dose-limiting Toxicities (DLTs)
Measured over Cycle 1 (28 days/cycle)
+1 more outcome measured
Platinum-resistant Ovarian Cancer
15 sites across 10 states
Spain6
Arkansas1
Connecticut1
Florida1
Massachusetts1
Michigan1
Minnesota1
Virginia1
  • Medical Director · STUDY_DIRECTOR · Stemline Therapeutics, Inc.

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Eligibility criteria

Inclusion

Participants must have a histopathologically confirmed diagnosis of high-grade serous ovarian cancer, primary peritoneal cancer, or fallopian tube cancer.

Exclusion

Participants with primary platinum-refractory disease.
  • Part A Only: Number of Participants with Dose-limiting Toxicities (DLTs)Cycle 1 (28 days/cycle)
  • Part B Only: Recommended Phase 2 Dose (RP2D) of MEN2501Up to approximately 6 months