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Study of BMS-986435 Bioavailability and Food Effect in Healthy Adults

This study is testing different tablet forms of BMS-986435 to see how well your body absorbs the medicine. It will also look at how food affects the absorption of BMS-986435. Researchers will measure the amount of BMS-986435 in your blood (Cmax, AUC(0-T), AUC(INF)) for up to 28 days to understand its absorption. You may be able to join if you are a healthy adult between 18 and 60 years old, weigh at least 45 kg, and have a BMI between 18 and 32. You must also have a healthy heart, including a left ventricular ejection fraction (LVEF) of 60% or more. The study plans to enroll 140 participants, but its current recruitment status is unclear.

Study design
This is an interventional study involving 140 healthy adult participants. It compares different tablet formulations of BMS-986435 and assesses the effect of food on the drug.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for the study will be taken for up to 28 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07226817

A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants

Recruiting
PHASE1Ages 18–60InterventionalTreatment
Bristol-Myers Squibb
~240 participants
Updated 2026-08-12 on ClinicalTrials.gov
What's tested:BMS-986435

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximum observed concentration (Cmax)
Measured over Up to Day 28
+2 more outcomes measured

Conditions

Healthy Volunteers

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Healthy Volunteers

NCT07226817

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Quotient Miami

    Miami, Floridano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Bristol-Myers Squibb · STUDY_DIRECTOR · Bristol-Myers Squibb

Who to contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
[email protected]
855-907-3286
Email the study team

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Eligibility criteria

Inclusion

Participants must have a body weight of ≥ 45 kg and BMI between 18 and 32 kg/m2, inclusive
Participants must be healthy as determined by medical history, physical examination, vital signs, 12-lead electrocardiogram (ECG), clinical laboratory assessments
Participants must have documented left ventricular ejection fraction (LVEF) ≥ 60% and absence of significant cardiac abnormality at screening, as determined by local transthoracic echocardiogram (TTE) assessment

What this trial measures

  • Maximum observed concentration (Cmax)Up to Day 28
  • Area under the concentration-time curve from time zero to time of last quantifiable concentration (AUC(0-T))Up to Day 28
  • Area under the concentration-time curve from time zero extrapolated to infinite time (AUC(INF))Up to Day 28