A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

This study is testing a new oral medication called LY4584180, sometimes given with Rituximab (an IV infusion), for adults with certain blood cancers like Lymphoma, Non-Hodgkin's, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma. You may be able to join if you've already had at least two other treatments for your blood cancer or can't receive other available therapies. Researchers want to see how safe LY4584180 is, how well it works to shrink tumors, and how your body processes the medication. The study will track side effects and how many participants respond to the treatment. The status of this study is currently unclear.

Study design
This is an interventional study planning to enroll 460 participants. The phase of the study is not specified.
What's involved
The study could last about 9 months or possibly longer, including an initial screening period. Specific details about visits, procedures, or tests are not provided.
Compensation
Not stated in the trial record.
Follow-up
Participants will be monitored for serious side effects for up to 3 years. Tumor response will also be evaluated for up to 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07226843

A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

Recruiting
PHASE1Ages 18+InterventionalTreatment
Eli Lilly and Company
~460 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:LY4584180Rituximab

At a glance

Recruiting sites
17 of 46 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Dose-Limiting Toxicities (DLTs) and DLT-Equivalent Toxicities
Measured over Baseline up to Day 28
+2 more outcomes measured
Lymphoma, Non-Hodgkin's
Lymphoma, Diffuse Large B-Cell
Follicular Lymphoma
46 sites across 21 states
France5
United Kingdom5
Germany4
Poland4
California3
Japan3
Florida2
Massachusetts2
  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company
Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Has been treated for the following blood cancers and has received at least 2 prior lines of systemic therapy or not eligible for available therapy:
Diffuse large B-cell lymphoma - not otherwise specified
High-grade B-cell lymphoma
Diffuse large B-cell lymphoma - transformed from indolent lymphomas
Follicular large B-cell lymphoma
Follicular lymphoma
Other non-Hodgkin lymphoma
Has measurable disease
Has discontinued all previous treatments for cancer and has recovered from the immediate effects of therapy

Exclusion

Has an active second cancer
Has known central nervous system (CNS) involvement by systemic lymphoma. Patients with previous treatment for CNS involvement who are neurologically stable and without evidence of active CNS disease may be eligible and enrolled if a compelling clinical rationale is provided by the Investigator and with documented Sponsor approval.
Has known Cytomegalovirus infection. Participants with negative status are eligible
Has known hepatitis B or C infection or uncontrolled HIV
Has known significant heart disease
  • Number of Dose-Limiting Toxicities (DLTs) and DLT-Equivalent ToxicitiesBaseline up to Day 28

    Number of Dose-Limiting Toxicities (DLTs) and DLT-Equivalent Toxicities

  • Number of Participants with One or More Serious Adverse Events (SAEs) Considered by the Investigator to be Related to Study Drug AdministrationBaseline up to 3 Years

    Number of Participants with One or More Serious Adverse Events (SAEs) Considered by the Investigator to be Related to Study Drug Administration

  • To Evaluate the Preliminary Antitumor Activity of LY4584180: Objective Response Rate (ORR)Baseline up to 3 Years

    To Evaluate the Preliminary Antitumor Activity of LY4584180: Objective Response Rate (ORR)