Body Composition and Exercise with GLP1 Agonist Treatment

This study is looking at whether using a smartwatch to track activity and body composition, along with exercise guidance, can help people maintain or build muscle while taking incretin therapy (like liraglutide, semaglutide, tirzepatide, or retatrutide). These medications are often used for obesity. We want to see if this approach can safely improve strength and muscle mass. You could join if you are 18 to 99 years old and have recently started, or are planning to start, one of these incretin therapies within the last two months. The main goal is to measure changes in lean muscle mass after 6 months.

Study design
This interventional study plans to enroll 100 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will be given a smartwatch to monitor exercise and body composition, and will receive general guidance on recommended exercise.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 6 months, suggesting follow-up for at least this duration.

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NCT07226947

Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

Recruiting
NAAges 18–99InterventionalTreatment
Massachusetts General Hospital
~100 participants
Updated 2025-12-30 on ClinicalTrials.gov
What's tested:Smartwatch activity and body composition monitorGeneral guidance on recommended exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Lean mass (kg)
Measured over 6 months
Obesity
Body Composition
1 sites across 1 states
Massachusetts1
  • Melissa Putman, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • Lean mass (kg)6 months

    Dual-energy X-ray absorptiometry (DXA) body composition measure