Methadone for Post-Surgery Pain After Hip Replacement

This study is looking at whether giving methadone (a pain medication) during total hip replacement surgery can reduce pain and the need for other opioid pain medicines afterward. You might be able to join if you are between 18 and 75 years old and are having an elective total hip replacement with a specific type of spinal anesthesia. The researchers want to see if methadone helps with your pain levels in the recovery room within 24 hours after surgery. This study plans to enroll 162 people, but its current status is unclear.

Study design
This is a randomized, double-blind controlled trial, meaning participants are randomly assigned to groups and neither you nor your doctors will know which treatment you receive. It plans to enroll 162 participants.
What's involved
Patients will receive an intravenous (IV) dose of methadone during their total hip replacement surgery. Your pain will be measured in the recovery unit after surgery.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be measured for up to 24 hours after surgery ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07227064

Methadone in THA for Post-op Pain and Opioid Reduction

Recruiting
PHASE3Ages 18–75InterventionalTreatment
Medical University of South Carolina
~162 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:Methadone

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient reported pain in the recovery unit after surgery
Measured over up to 24 hours after surgery ends
Post Operative Pain
Total Hip Arthroplasty
1 sites across 1 states
South Carolina1
  • Christopher Fatora, MD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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  • Patient reported pain in the recovery unit after surgeryup to 24 hours after surgery ends

    Patient reported hip pain on a Visual Analog Scale (VAS) from 0-100mm at approximately 30-60 minutes after arriving to the recovery unit after surgery. A lower pain score means a better outcome.