This study, called The HOPE Biobank Resource, is creating a collection of biological samples (like blood) and health information from people who are getting a hematopoietic stem cell transplant (HCT) or gene therapy (GT) for non-cancerous blood diseases. These diseases include Aplastic Anemia, hemoglobinopathies, and other bone marrow failures. The goal is to better understand why these treatments sometimes don't work as expected and to find new ways to improve them. Researchers hope to identify new treatment targets within five years. You could be eligible if you have one of these conditions and are undergoing HCT or GT. This is an observational study, meaning there are no new treatments given as part of the study; your doctors will decide your care.

Study design

This is a prospective, multicenter, observational study aiming to enroll 375 participants and about 100 related donors.

What's involved

You will provide blood and other biological samples at specific times before and after your HCT or GT. You will be followed until the end of the study, potentially for up to 15 years.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed until the end of the study, with potential for up to 15 years of follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.