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Observational Study on Opioid Timing and Breathing After Surgery

This study is looking at how the timing of opioid pain medication affects breathing problems after surgery. Researchers want to see if there's a link between when you receive an opioid and changes in your breathing, specifically a decrease in how much air you breathe out (minute ventilation). They will use a non-invasive monitor to track your breathing. You might be able to join if you are between 18 and 85 years old, having general anesthesia for at least 2 hours, and are expected to receive opioids for pain after surgery. The goal is to understand if the timing of opioids causes breathing issues within 4 hours of arriving in the Post Anesthetic Care Unit (PACU). This study is currently unclear on its recruitment status.

Study design
This is an observational study involving 52 participants. It is not a drug trial, but rather observes how patients respond to standard care.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your breathing will be monitored within 4 hours of being admitted to the Post Anesthetic Care Unit (PACU).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07227389

Timing of Opioid Administration and Postoperative Respiratory Depression.

Recruiting
Not specifiedAges 18–85Observational
Wayne State University
~52 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Respiratory volume monitoring

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Respiratory interventions 1
Measured over Within 4 hours of patient admittance to Post Anesthetic Care Unit (PACU)
+3 more outcomes measured

Conditions

Respiratory Complications
Opioid Induced Respiratory Depression
Postoperative Respiratory Complications

Explore related trials

Opioid Induced Respiratory DepressionPostoperative Respiratory ComplicationsRespiratory complication

Where it's being run

1 sites across 1 states
Michigan1

Study leadership

  • Wael Saasouh, MD · PRINCIPAL_INVESTIGATOR · Wayne State University

Who to contact

George M McKelvey, PhD
[email protected]
3135986036
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Written informed consent
Adults ≥18 years of age and ≤85 years of age
Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours
Patients expected to receive postoperative opioid analgesia

Exclusion

Non-operative procedure (imaging)
Patients not admitted to the PACU postoperatively
Use of patient-controlled analgesia systems
Female patients who are pregnant or breastfeeding
Patients with asymmetric lung disease
American Society of Anesthesiologists (ASA) classification V
Emergency surgery (ASA E Modifier)

What this trial measures

  • Respiratory interventions 1Within 4 hours of patient admittance to Post Anesthetic Care Unit (PACU)

    Initiation or cessation of mechanical ventilation

  • Respiratory interventions 2Within 4 hours of patient admittance to Post Anesthetic Care Unit

    Initiation or cessation of Bilevel Positive Airway Pressure

  • Respiratory interventions 3Within 4 hours of patient admittance to Post Anesthetic Care Unit

    Initiation/cessation of high flow nasal cannula

  • Respiratory interventions 4Within 4 hours of patient admittance to Post Anesthetic Care Unit

    Initiation/cessation of low flow nasal cannula