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Observational Study of Chronic Infections and Inflammation in ME/CFS

This study, called CHIIME, is looking at people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and healthy individuals to understand the long-term biological reasons and effects of ME/CFS. Researchers will observe participants over time and collect samples to learn more about the condition. The main goal is to identify the biological and physical processes that cause ME/CFS. You can join if you are at least 18 years old and either have a diagnosis of ME/CFS or do not have ME/CFS or other chronic infection-related conditions. The study is currently unclear about its recruitment status and is not testing any specific drugs or interventions. Success for this study will be measured by gathering information about participants' sex, age, and race/ethnicity at the start of the study.

Study design
This is an observational study planning to enroll 200 participants, including those with ME/CFS and healthy controls.
What's involved
You would have visits at San Francisco General Hospital, which include a detailed interview, collection of biospecimens (like blood or urine), and various assessments.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07227441

Chronic Infections and Inflammation in ME/CFS: An Observational Study

Recruiting
Not specifiedAges 18+Observational
University of California, San Francisco
~200 participants
Updated 2026-03-06 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Participant Sex
Measured over Baseline Visit
+2 more outcomes measured

Conditions

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Explore related trials

Chronic Fatigue Syndrome

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Michael J. Peluso · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Beatrice Program Manager
[email protected]
(415) 502-2449
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Willing and able to provide written informed consent
At least 18 years of age
Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control)

Exclusion

Self reported or documented chronic anemia with hemoglobin \<9 g/dL
Known HIV, hepatitis B, or hepatitis C infection
Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)
Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent
Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent

What this trial measures

  • Participant SexBaseline Visit

    The proportion of men and women participating in the baseline visit.

  • Participant AgeBaseline Visit

    The median age of study participants at enrollment.

  • Participant race/ethnicityBaseline Visit

    The proportion of participants from each demographic group.