NAC-REPAIR for Post-surgical Pain after Hand/Foot-Ankle Surgery
This study is investigating if N-acetylcysteine (NAC), a capsule taken by mouth, can help reduce pain and opioid use, and improve recovery after common outpatient hand or foot/ankle surgeries. You would take NAC or a matching placebo (an inactive capsule) twice daily for 15 days, starting the evening before your surgery. The study aims to see how well NAC works compared to placebo and to understand if it affects inflammation. Researchers will measure your pain levels, how well you can use your hand or foot, and your opioid use. This study is currently recruiting about 80 participants aged 18 to 75 who are having elective outpatient hand/upper-extremity or foot/ankle surgery.
- Study design
- This is a single-site, double-blind (meaning neither you nor your doctor will know if you're getting NAC or placebo), randomized trial with about 80 participants.
- What's involved
- You would take capsules twice daily for 15 days, complete daily electronic diaries for 14 days after surgery, and have small blood draws before surgery and at two follow-up visits.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your pain interference will be measured at baseline, 2-4 weeks after surgery, and 12 weeks after surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
NAC-REPAIR for Post-surgical Pain
At a glance
Conditions
NCT07227649
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Banner Health
Tucson, Arizonastudy coordinator listed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- PROMIS pain interferencebaseline; post-op (2-4 weeks); post-op (12 weeks);
Patient-Reported Outcomes Measurement Information System - Pain Interference T-score metric: mean = 50, SD = 10 Higher scores = worse outcome (greater pain interference with daily activities, social, cognitive, emotional, and physical functioning)