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Comparing Dexamethasone and Prednisone for Asthma in the Emergency Department

This study is looking at adults who come to the emergency department (ED) with an asthma attack. It compares two ways to give steroids: a single shot of Dexamethasone (16mg IM) or taking Prednisone (60mg by mouth) for 5 days. The goal is to see if the single shot of Dexamethasone works just as well as the 5-day Prednisone course in preventing you from needing to return to the ED for asthma. You could join if you are 18 or older, have asthma, and are discharged from the ED after an asthma attack where you received steroids. The study will measure your Asthma Control Test Score within 4 weeks after you leave the hospital to see how well your asthma is managed. The current status of this study is unclear.

Study design
This is a randomized, controlled, double-blind study comparing two treatments. It plans to enroll 182 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your asthma control will be checked within 4 weeks (up to 28-30 days) after you leave the hospital.

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NCT07228052

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

Recruiting
PHASE4Ages 18+InterventionalTreatment
Montefiore Medical Center
~182 participants
Updated 2026-07-24 on ClinicalTrials.gov
What's tested:Dexamethasone 16mg IMPrednisone 60mg PO

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Asthma Control Test Score
Measured over Within 4 Weeks post-discharge, up to 28-30 days

Conditions

Asthma

Explore related trials

Asthma

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Carlo Lutz, MD · PRINCIPAL_INVESTIGATOR · Montefiore Medical Center

Who to contact

Mustfa Manzur, MD MPH MS
[email protected]
718-920-6626
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults ≥18 years old presenting to the ED with an asthma exacerbation
Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
Discharged from the ED with a primary diagnosis of asthma exacerbation
Initiated systemic corticosteroids during the ED visit
Must be English or Spanish speaking

Exclusion

Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
History of severe adverse reactions to corticosteroids
Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED)
Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
Inability to provide informed consent

What this trial measures

  • Asthma Control Test ScoreWithin 4 Weeks post-discharge, up to 28-30 days

    Asthma control will be assessed via administration of the Asthma Control Test (ACT) questionnaire at 4 weeks post-discharge. The ACT questionnaire is comprised of 5 questions which ask participants to recall how asthma symptoms have affected them over the prior 4 weeks. Responses to the 5 questions are rated on a 5-point Likert scale ranging from 1-5, yielding an overall possible scoring range of 5-25. Higher ACT scores are indicative of better asthma control. For this study, an ACT score \>19 indicates well-controlled asthma. Scores will be summarized by study arm using basic descriptive statistics.