Understanding Blood Pressure Responses in Type 2 Diabetes

This study is looking at why people with Type 2 Diabetes (T2DM) sometimes have high blood pressure during exercise, which can increase their risk of heart problems. Researchers want to see if issues with blood vessel function and cell damage are causing these high blood pressure responses. You might be eligible if you are 18-80 years old and have Type 2 Diabetes or are a healthy control. Participants will receive either an over-the-counter antioxidant supplement called MitoQ or a placebo (an inactive substance) to see how it affects blood flow and muscle function. The main goal is to measure changes in your blood pressure and heart rate before and 45 minutes after taking the supplement. The study is currently unclear on its recruitment status and plans to enroll 40 people.

Study design
This is an interventional study planning to enroll 40 participants, including individuals with Type 2 Diabetes and healthy controls. Participants will receive either MitoQ or a placebo.
What's involved
During each testing session, you will orally take either MitoQ or a placebo. Researchers will measure your blood pressure and heart rate before and 45 minutes after taking the supplement.
Compensation
Not stated in the trial record.
Follow-up
Measurements for primary endpoints (blood pressure and heart rate) are taken prior to and 45 minutes following supplement administration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07228208

Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes

Not Yet Recruiting
NAAges 18–80InterventionalBasic science
Medical College of Wisconsin
~40 participants
Updated 2025-11-14 on ClinicalTrials.gov
What's tested:MitoQ (mitoquinol mesylate)Placebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean Arterial Pressure
Measured over Prior to and 45 minutes following supplement
+1 more outcome measured
Type 2 Diabetes (T2DM)
Endothelial Dysfunction
1 sites across 1 states
Wisconsin1
  • William E Hughes, Ph.D. · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin

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Eligibility criteria

Inclusion

Type 2 Diabetes: 18 - 80 years old, able to give informed consent, \> 6 months post-diagnosis, \> 6 months stable medications for management
Healthy controls: 18 - 80 years old, able to give informed consent

Exclusion

Type 2 Diabetes: Type 1 diabetes, symptomatic coronary artery disease, cardiovascular event in last year (MI, stroke), uncontrolled or unmanaged hypertension (\>160/90 mmHg), heart failure, renal impairments, current or recent (\<6 months) tobacco use, hormone replacement therapy, documented neuromuscular disorders, pregnancy
Healthy Controls: Same as listed in Type 2 Diabetes with Type 2 Diabetes as an exclusion factor
  • Mean Arterial PressurePrior to and 45 minutes following supplement

    Change in mean arterial pressure is measured in response to handgrip exercise and post-exercise circulatory occlusion

  • Heart RatePrior to and 45 minutes following supplement

    Change in heart rate is measured in response to handgrip exercise and post-exercise circulatory occlusion