Cobenfy KarXT for Memory in Epilepsy Patients
This study is investigating how a drug called COBENFY KarXT (xanomeline and trospium chloride) affects memory and brain activity in people with epilepsy. Researchers want to see if COBENFY KarXT, which works on certain brain receptors (muscarinic receptors and acetylcholine), can improve memory-related brain activity. You might be eligible if you are between 18 and 75 years old and are already scheduled for brain surgery to monitor your seizures (intracranial electrodes) as part of your regular medical care. The study will measure changes in your brain's electrical activity related to memory after you take the drug or a placebo (an inactive pill). The study aims to enroll 50 participants, but its current recruitment status is unclear.
- Study design
- This interventional study will involve 50 participants who will be randomly assigned to receive either COBENFY KarXT or a placebo. It is not specified if participants or researchers will know which treatment is given.
- What's involved
- You would receive either COBENFY KarXT or a placebo, and then complete an episodic memory task about 2 hours later. Your participation would only occur while your intracranial electrodes are surgically in place for seizure monitoring.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your memory-related brain activity will be measured at baseline and then again within 1-3 hours after taking the intervention on Day 1 and Day 2.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cholinergic Enhancement of Theta
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Bradley C Lega, MD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center
Who to contact
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What this trial measures
- Memory-related changes in brain electrical activity in participants from baseline at Day 1 post-intervention (approx. within 1-3 hrs)Baseline, at Day 1 post-intervention (approx. within 1-3 hrs)
Memory-related changes in brain electrical activity in participants from baseline at post-intervention (approx. within 1-3 hrs) is measured by comparing the Free recall memory tasks with the electrical readings collected across all bandwidths, but focusing on primarily theta power and oscillatory changes. Other changes, such as phase amplitude coupling, may also be considered.
- Memory-related changes in brain electrical activity in participants from baseline at Day 2 post-intervention (approx. within 1-3 hrs)Baseline, at Day 2 post-intervention (approx. within 1-3 hrs)
Memory-related changes in brain electrical activity in participants from baseline at post-intervention (approx. within 1-3 hrs) is measured by comparing the Free recall memory tasks with the electrical readings collected across all bandwidths, but focusing on primarily theta power and oscillatory changes. Other changes, such as phase amplitude coupling, may also be considered.
- Memory-related changes in brain electrical activity in participants from baseline at Day 1 post-intervention (approx. within 1-3 hrs)Baseline, at Day 1 post-intervention (approx. within 1-3 hrs)
Memory-related changes in brain electrical activity in participants from baseline at post-intervention (approx. within 1-3 hrs) is measured by comparing the serial recall memory tasks with the electrical readings collected across all bandwidths, but focusing on primarily thetapower and oscillatory changes. Other changes, such as phase amplitude coupling, may also be considered.
- Memory-related changes in brain electrical activity in participants from baseline at Day 2 post-intervention (approx. within 1-3 hrs)Baseline, at Day 2 post-intervention (approx. within 1-3 hrs)
Memory-related changes in brain electrical activity in participants from baseline at post-intervention (approx. within 1-3 hrs) is measured by comparing the serial recall memory tasks with the electrical readings collected across all bandwidths, but focusing on primarily theta power and oscillatory changes. Other changes, such as phase amplitude coupling, may also be considered.
- Memory-related changes in brain electrical activity in participants from baseline at Day 1 post-intervention (approx. within 1-3 hrs)Baseline, at Day 1 post-intervention (approx. within 1-3 hrs)
Memory-related changes in brain electrical activity in participants from baseline at post-intervention (approx. within 1-3 hrs) is measured by comparing the associative recognition memory tasks with the electrical readings collected across all bandwidths, but focusing on primarily theta power and oscillatory changes. Other changes, such as phase amplitude coupling, may also be considered.
- Memory-related changes in brain electrical activity in participants from baseline at Day 2 post-intervention (approx. within 1-3 hrs)Baseline, at Day 2 post-intervention (approx. within 1-3 hrs)
Memory-related changes in brain electrical activity in participants from baseline at post-intervention (approx. within 1-3 hrs) is measured by comparing the associative recognition memory tasks with the electrical readings collected across all bandwidths, but focusing on primarily theta power and oscillatory changes. Other changes, such as phase amplitude coupling, may also be considered.