Back to search results
NCT07229482

Potatoes, Type 2 Diabetes, and Cardiometabolic Health

Recruiting
NAAges 50–70InterventionalPrevention
Virginia Polytechnic Institute and State University
~42 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:Controlled diet: Potato-rich healthy dietary patternControlled diet: Typical Western-style dietary pattern

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in glucose tolerance from baseline to 12 weeks post potato-rich healthy diet vs typical Western-style diet
Measured over 2-hour test in laboratory, 2 timepoints (baseline, 12-weeks post intervention diets)
+3 more outcomes measured

Conditions

T2D
Blood Pressure
Cardiometabolic Health

Explore related trials

Cardiometabolic HealthHypertensionType 2 Diabetes Mellitus

Where it's being run

1 sites across 1 states
Virginia1

Study leadership

  • Dennis Cladis, PhD · PRINCIPAL_INVESTIGATOR · Virginia Polytechnic Institute and State University

Who to contact

Dennis Cladis, PhD
[email protected]
540-231-5208
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 50-70 years
Weight stable for previous 3 months (±5% body weight)
Sedentary to recreationally active
ADA-Risk Screener questionnaire score of at least 5
No plans to gain or lose weight or change physical activity level
Willing to pick up food daily and consume foods provided for a 14-week period
Verbal and written informed consent
Estrogen or testosterone use, lipid-lowering or blood pressure medication and thyroid replacement medication is acceptable, if on stable dose for \>6 months

Exclusion

Body mass index \>40 m2/kg
Diabetes or diabetes medication
Weight loss medication or medication influencing glucose metabolism
Antibiotic, prebiotic or probiotic use in prior 3 months
TCHOL \>6.2 mmol/L; TG \>4.5 mmol/L
Blood pressure (BP) \> 159/99 mmHg
Diagnosed inflammatory bowel disease
Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease
Vegetarian or vegan
Pregnant or plans to become pregnant
Food allergies or aversions to diet foods provided
Estrogen or testosterone usage, lipid-lowering medication, blood pressure medication usage \<6 months

What this trial measures

  • Change in glucose tolerance from baseline to 12 weeks post potato-rich healthy diet vs typical Western-style diet2-hour test in laboratory, 2 timepoints (baseline, 12-weeks post intervention diets)

    Glucose tolerance will be assessed using a 2-hour oral glucose tolerance test (OGTT, 75 g glucose load). Blood will be collected at baseline (fasting) and thereafter at 30-minute intervals (5 total measurements in 2 hours).

  • Change in insulin sensitivity from baseline to 12 weeks post potato-rich healthy diet vs typical Western-style diet2-hour test in laboratory, 2 timepoints (baseline, 12-weeks post intervention diets)

    Insulin sensitivity will be assessed using a 2-hour oral glucose tolerance test (OGTT, 75 g glucose load). Blood will be collected at baseline (fasting) and thereafter at 30-minute intervals (5 total measurements in 2 hours).

  • Change in glucose control (AUC) from baseline to 12 weeks post potato-rich healthy diet vs typical Western-style diet7-day measurement during free-living, 2 timepoints (baseline, 12 weeks post intervention diets)

    24-hour glucose control (24-hour AUC) will be assessed using continuous glucose monitoring for a 7-day period.

  • Change in blood pressure from baseline to 12 weeks post potato-rich healthy diet vs typical Western-style diet20-minute measurement in the laboratory, 2 timepoints (baseline, post 12 week intervention diets)

    Seated, resting blood pressure will be measured via automated sphygmomanometry, according to American Heart Association guidelines. Both diastolic and systolic blood pressures will be measured.