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Grape Consumption and Gut Health in Obesity Study

This study is looking at how eating freeze-dried grape powder might affect your gut and immune system if you have obesity. Researchers want to see if consuming 48 grams of freeze-dried grape powder daily for four weeks can change the types of bacteria in your gut (gut microbial diversity), reduce inflammation markers like LPS-binding protein, and affect immune cell responses (cytokine concentrations). You might be able to join if you are 30-45 years old, have obesity (BMI 30-45 kg/m2), and don't regularly eat grapes. The study aims to enroll 50 participants, but its current recruitment status is unclear.

Study design
This is a randomized, controlled, crossover study involving 50 participants. You would receive either the grape powder or a placebo first, then switch after a break.
What's involved
You would consume either freeze-dried grape powder or a placebo powder daily for two separate 4-week periods, with a 4-week break in between. Measurements will be taken at baseline, Week 4, Week 8, and Week 12.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken at Week 4, Week 8, and Week 12, which is after the active treatment periods.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07231484

Effects of Grape Consumption on the Immune-Gut Axis in Obesity

Recruiting
NAAges 18–60InterventionalTreatment
University of Missouri-Columbia
~50 participants
Updated 2026-07-31 on ClinicalTrials.gov
What's tested:Freeze-dried grape powderPlacebo powder

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Gut microbial diversity
Measured over Baseline, Week 4, Week 8, Week 12
+3 more outcomes measured

Conditions

Obesity &Amp; Overweight

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
Missouri1

Who to contact

Jaapna Dhillon PhD, PhD
[email protected]
573-884-2103
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age: 18-60 years
Obesity with BMI of 30-45 kg/m2
Willingness to consume study foods
Consistent diet and activity patterns for 4 weeks
Weight stable (\<5kg change over last 3 months)
Non-smoker \> 1 year or more
Not currently consuming an extremely healthy diet

Exclusion

Study food allergies
Regular consumption of grapes or grape-derived products
Gastrointestinal disease and/or bariatric surgery
Uncontrolled hypertension and blood pressure \>180/110
Diabetes
Illicit drug use
History of alcohol or drug abuse
Recent use of medications that affect immune function (e.g., corticosteroids)
Recent consumption of antibiotics, prebiotics, probiotics, symbiotics, or dietary supplements containing fiber or phytochemicals
Pregnant or lactating individuals
HIV positivity
Recent start of medications that affect metabolism or appetite
Drug therapy for coronary artery disease, peripheral artery disease, congestive

What this trial measures

  • Gut microbial diversityBaseline, Week 4, Week 8, Week 12

    Assessed via 16s rRNA sequencing

  • LPS-binding protein concentrationBaseline, Week 4, Week 8, Week 12

    Intestinal permeability marker

  • Cytokine concentrations following PBMC stimulationBaseline, Week 4, Week 12

    IL-6, IL-10

  • Perceived stress scoreBaseline, Week 4, Week 8, Week 12

    Assessed using validated Cohen's Perceived Stress Scale. Scores range from 0-56 with higher scores indicating greater stress perceptions.