Observational Study for Kidney Cancer Classification
This study is looking for better ways to tell the difference between benign (non-cancerous) and malignant (cancerous) kidney tumors, and to predict if kidney cancer will spread after surgery. Researchers are studying proteins found in tiny particles called extracellular vesicles (EVs) from urine, and also collecting blood samples before and after kidney removal surgery (nephrectomy). This study is for people with high-risk kidney cancer who are scheduled for nephrectomy and have a urine sample already stored in a biorepository. The goal is to find protein markers that could lead to new, non-invasive tests for kidney cancer.
- Study design
- This is an observational study aiming to enroll 300 participants. It is a correlative (lab-based) study.
- What's involved
- You would provide blood samples before and after your nephrectomy. Urine samples from an existing collection will also be used.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study measures outcomes at baseline and around the time of surgery (pre- and post-nephrectomy).
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Tumor-Derived Extracellular Vesicles for Noninvasive Molecular Classification of Kidney Cancer
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Fabrice Lucien-Matteoni, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- Differentiate tumor-derived extracellular vesicle (tdEV) surface proteins expressed in benign vs malignant renal tumorsBaseline
Differential protein expression analysis will be performed on stored urine samples from a biorepository to identify tdEV proteins in each renal cell carcinoma (RCC) subtype (clear-cell, papillary, and chromophobe) versus benign.
- Prediction of metastasis after surgeryPerioperative (pre- and post-nephrectomy),
Blood samples will be collected pre-and post-nephrectomy to asses for tdEV levels which will be correlated with clinicopathological features to test whether tdEV levels can be used to better predict likelihood of metastasis in patients undergoing curative-intent radical nephrectomy.