Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage

This study is looking at whether giving nicardipine (a medication) directly into the spinal fluid can help prevent problems after a subarachnoid hemorrhage (bleeding in the space around the brain, often from a burst aneurysm). You might be able to join if you are at least 18 years old, have had this type of bleeding with a specific severity (Hunt and Hess score 3 or less), and have a lumbar drain (a small tube in your lower back to drain spinal fluid) in place or planned. The study aims to see if nicardipine can reduce vasospasm (narrowing of blood vessels in the brain) and delayed cerebral ischemia (brain injury due to reduced blood flow). The current status of this study is unclear.

Study design: This is a triple-blinded, randomized study involving about 214 participants. Participants will either receive nicardipine or a saline solution through their lumbar drain.
What's involved: Participants will receive either nicardipine or normal saline every 24 hours from randomization through day 14 post-bleed or until their lumbar drain is removed, whichever comes first.
Compensation: Not stated in the trial record.
Follow-up: The study will measure outcomes like vasospasm and delayed cerebral ischemia up to hospitalization day 21.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage

Not Yet Recruiting

PHASE4Ages 18+InterventionalPrevention

Wake Forest University Health Sciences

~214 participants

Updated 2026-07-30 on ClinicalTrials.gov

What's tested:Normal SalineNicardipine

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Incidence of Vasospasm

Measured over up to hospitalization day 21

+1 more outcome measured

Conditions

Subarachnoid Hemorrhage

Where it's being run

1 sites across 1 states

Illinois1

Study leadership

Krishna Joshi, MD · PRINCIPAL_INVESTIGATOR · Advocate Lutheran General Hospital

Who to contact

Sajid Suriya, MD

[email protected]

847-723-2078

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

Age ≥18 years

Aneurysmal subarachnoid hemorrhage with Hunt and Hess score 3 or less

Patient or legal authorized representative available to sign the informed consent form

Pre-morbid modified Rankin scale of 0 or 1.

Patients who have lumbar drain placed or planned for cerebrospinal fluid diversion per standard of care

Patients who are able to be randomized within 72 hours from arrival with aneurysmal subarachnoid hemorrhage or within 24 hours from lumbar drain placement

Exclusion

Pregnant females

Subarachnoid hemorrhage (SAH) with hunt and hess scale of \>3

SAH due to etiology other than aneurysmal rupture

Any contraindications in patients receiving calcium channel antagonists like hypersensitivity to dihydropyridines

Active central nerve infection (CNS) infection or high suspicion of CNS infection

Hemodynamic instability preventing the use of Nicardipine

What this trial measures

Incidence of Vasospasmup to hospitalization day 21
The incidence of symptomatic clinical or radiographic vasospasm in patients treated with prophylactic administration of intrathecal nicardipine though lumbar drain
Incidence of Delayed Cerebral Ischemiaup to hospitalization day 21
The incidence of symptomatic clinical or radiographic delayed cerebral ischemia in patients treated with prophylactic administration of intrathecal nicardipine though lumbar drain

Trialytics