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Understanding Sepsis and Complications After Burn Injury

This study is observing adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery. Researchers will collect small amounts of blood and tissue samples, along with information already recorded in your medical record, such as vital signs and lab results. The goal is to identify patterns that may help predict who is at higher risk for infections (sepsis) or other problems after a burn injury. This information could lead to new tools, including computer models, to improve burn care and outcomes in the future. You would receive standard burn care only; no new drugs or devices are being tested. The study is currently unclear on its recruitment status.

Study design
This is an observational study involving about 40 participants. It is not testing any new treatments, but rather collecting information from patients receiving standard care.
What's involved
You would provide blood and tissue samples (when medically necessary) and allow researchers to review your medical records during your hospital stay and for up to one year after discharge.
Compensation
Not stated in the trial record.
Follow-up
Researchers will follow your health during your hospitalization and for up to 12 months after you leave the hospital.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07249762

Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1

Not Yet Recruiting
Not specifiedAges 18–80Observational
Henry M. Jackson Foundation for the Advancement of Military Medicine
~40 participants
Updated 2026-02-04 on ClinicalTrials.gov
What's tested:Observational Cohort (No Intervention)

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Sepsis and Other Major Complications After Burn Injury
Measured over During hospitalization, up to 12 months after discharge

Conditions

Sepsis
Burn Injury
Wound Healing
Critical Illness
Multiple Organ Dysfunction Syndrome

Explore related trials

Acute Respiratory Distress SyndromeBurnMultiple Organ FailureSepticemia

Where it's being run

3 sites across 3 states
Florida1
Georgia1
Texas1

Who to contact

Seth Schobel-McHugh, PhD
[email protected]
(301) 295-3164
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Burn Injury \>10% TBSA with who have a recognized concurrent or impending risk for clinical decompensation.
Male and female ages 18 years and older (maximum age of 80 years old) with burn injury or related illness requiring surgical care or treatment in a critical care or emergency setting who are being cared for at an SC2i-member clinical care facility (Emory/Grady, USF and USAISR) will be considered for study.
Ability to understand the purposes and risks of the study and to provide informed consent, either through written documentation or in accordance with the IRB-approved Waiver of Documentation of Consent procedures. In the case of incapacitated patients, a willing Legally Authorized Representative (LAR) may provide informed consent in accordance with written documentation or under the provisions of the approved Waiver of Documentation of Consent.

Exclusion

Any condition that, in the opinion of the attending physician, would place the patient or volunteer subject at undue risk by participating. Specific conditions include but are not limited to anemia prohibitive of phlebotomy, or technical considerations that would prevent acquisition of sufficient tissue for clinical use.
Pregnant patients
Minors \< 18 years of age
Prisoners

What this trial measures

  • Incidence of Sepsis and Other Major Complications After Burn InjuryDuring hospitalization, up to 12 months after discharge

    Clinical data will be collected from medical records to capture whether patients develop sepsis, organ dysfunction, or other serious complications following burn injury.