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rTMS-EEG for Visuomotor Integration in Brain Lesions

This study is testing a new way to use repetitive transcranial magnetic stimulation (rTMS) and electroencephalography (EEG) together. rTMS is a device that uses magnetic pulses to stimulate brain cells, and EEG measures brain waves. The goal is to see if applying rTMS at specific times, based on your brain's natural rhythms, can improve eye-hand control in people with brain lesions (areas of damage in the brain) affecting movement. We are looking for about 20 right-handed adults who can grip and release with some strength. We will measure changes in your hand grip precision and how different parts of your brain connect after 90 minutes to see if the treatment is successful. The study status is currently unclear.

Study design
This is a pilot study involving about 20 adult volunteers. It is a 'within-subject cross-over' design, meaning each participant will experience different conditions.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main measurements for this study are taken at 90 minutes after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07249801

Closed-loop rTMS-EEG During Visuomotor Integration.

Recruiting
NAAges 18+Interventional
Medical University of South Carolina
~20 participants
Updated 2026-09-15 on ClinicalTrials.gov
What's tested:repetitive transcranial magnetic stimulation (rTMS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change of whole hand grip force precision
Measured over 90 minutes
+1 more outcome measured

Conditions

Visuomotor Skills
Brain Lesion (General)

Explore related trials

Brain LesionUpper Extremity Sensorimotor Impairment

NCT07249801

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical University of South Carolina

    Charleston, South Carolinano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Kirstin-Friederike Heise, Ph.D. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Kirstin-Friederike Heise, PhD
[email protected]
843-792-3435
Email the study team

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Eligibility criteria

Inclusion

adult volunteers (age ≥18 years)
right-hand dominance (defined with the Edinburg Handedness Scale)
voluntary whole-hand grip force (Medical Research Council scale for muscle force ≥2)
capable of repeated grasp and release with 5% of maximum voluntary contraction (standardized with an in-house computer-based assessment involving whole-hand grip force tracking upon visual cues with a digital dynamometer).

Exclusion

presence of any MRI risk factors (such as an electrically, magnetically, mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, any other electrically sensitive support system, or claustrophobia)
presence of any contraindications to repetitive transcranial magnetic stimulation, rTMS (e.g., history of seizures or epileptic activity, currently taking medications that lower seizure thresholds)
any neurological or psychiatric disorders affecting cognitive function (e.g., established dementia) affecting the ability to understand the purpose of the study and give informed consent or ability to complete cognitive testing
substance use disorder
visual impairment that precludes completion of scanner tasks
uncontrolled hypertension despite treatment
intake of tricyclic anti-depressants
musculoskeletal disorders affecting bimanual grasp- and release
pregnancy (or suspected/possible pregnancy or plan to become pregnant in the short term). If the participant is a woman of childbearing potential, a urine pregnancy test will be performed on a standard basis.
severe aphasia affecting particularly of receptive nature (NIH Stroke Scale, NIHSS Language subsection ≥2) affecting the ability to understand the purpose of the study and give informed consent
pregnancy

What this trial measures

  • Change of whole hand grip force precision90 minutes

    Force time series will be used to extract two measures for each trial to describe distinct features of visuomotor force adjustment: 1) Root Mean Square Error (RMSE) to characterize the deviation of the actual force from the target force, i.e., over- and undershoot and 2) sample entropy (SmpEn) to quantify the randomness or uncertainty of the sampled force time series. From these measures, the trial-based relative changes in RMSE and SmpEn from baseline (before intervention) will be computed.

  • Change of functional brain connectivity.90 minutes

    Trial-specific phase-based connectivity will be extracted from the electroencephalography (EEG) time series and computed relative to baseline (before intervention).