Tirzepatide for Postmenopausal HR+ Breast Cancer Survivors with Obesity

This study is looking at whether tirzepatide, a medication given weekly, is a practical and acceptable treatment for postmenopausal women who have had hormone receptor-positive (HR+) breast cancer and also have obesity. Researchers want to see if participants are willing and able to take tirzepatide for 24 weeks (about 6 months), and if it helps with weight and overall health. You would have monthly check-ups. To join, you must be a woman aged 18 or older, postmenopausal, and have obesity (BMI of 30 or higher, or 27.5 or higher for Asian ancestry). The study aims to see how many participants complete all required assessments at 24 weeks. The current recruitment status is unclear.

Study design
This is an interventional study with 30 planned participants. It is exploring the use of tirzepatide in a specific group of women.
What's involved
You would take tirzepatide weekly for 24 weeks, with dose adjustments monthly. You would also have monthly check-ins, body composition assessments, blood tests, and provide a stool sample at the beginning and end of the study, along with completing surveys.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 24 weeks, indicating the duration of the study's active assessment period.

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NCT07257484

Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors

Recruiting
PHASE4Ages 18+InterventionalTreatment
Weill Medical College of Cornell University
~30 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Tirzepatide

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants completing week 24 visit with all required assessments
Measured over 24 weeks
Obesity (Disorder)
Breast Cancer
1 sites across 1 states
New York1
  • Sarah Schmitz, MD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

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Eligibility criteria

Inclusion

Biologically female
Age ≥ 18
Obesity as defined by current BMI ≥ 30 kg/m² or ≥ 27.5 kg/m² for individuals of Asian ancestry
Postmenopausal as defined by one or more of the following
Age ≥60 years
Age \<60 years with amenorrhea for ≥ 1 year
Documented bilateral surgical oophorectomy
Chemical menopause with the addition of LHRH agonists at least 12 weeks prior to enrolment, and plan to remain on LHRH agonists throughout the trial
HR+ (ER and/or PR) stage 0-III breast cancer
Completed curative treatment (surgery, chemotherapy, radiotherapy) at least 12 weeks prior to enrolment
Insurance approval for tirzepatide or willing to pay out of pocket
Willing to provide informed consent and comply with study procedures

Exclusion

Stage IV breast cancer
Concomitant use of CDK inhibitors
Concomitant use of antiHER2 therapy
The PI may be consulted regarding enrollment of females receiving other endocrine therapy medications
Other active malignancy requiring treatment
Enrollment in another investigational clinical trial
Contraindication to tirzepatide
Treatment with a GLP-1 receptor agonist within the last 3 months
Diabetes requiring insulin
  • Percentage of participants completing week 24 visit with all required assessments24 weeks