Topical Testosterone and Estrogen for Vulvodynia
This study is looking at how well two different creams work to reduce pain during vaginal penetration for women with vulvodynia (pain in the female vestibule, the area around the vaginal opening). We want to see if using a cream with both testosterone 0.1% and estradiol 0.01% is better than using estradiol 0.01% cream alone. You might be able to join if you are 18 or older, have vulvodynia with pain during vaginal penetration that rates 4 or higher, and are not pregnant or breastfeeding. We are looking for 44 participants. The main goal is to measure your typical pain with vaginal penetration after 12 weeks of treatment. The current recruitment status is unclear.
- Study design
- This is an interventional study comparing two different topical creams. It plans to enroll 44 women.
- What's involved
- You would apply 1 gram of cream to the vestibule twice daily for 12 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your pain will be measured at 12 weeks post-treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial
At a glance
Conditions
NCT07260825
Where you'd take part
This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Cincinnati Urogynecology Associates
Cincinnati, Ohiostudy coordinator listed
TriHealth
Cincinnati, Ohiono site contact published
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Typical pain with vaginal penetration within last 2 weeksat 12 weeks post-treatment
Typical pain with vaginal penetration within last 2 weeks using numeric rating scale