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Pollution Intervention to Impact Kids Asthma Study

This study is looking at whether providing information about the Air Quality Index (AQI) can help children aged 8 to 17 with asthma manage their condition better. Researchers want to see if adding either the EPA-AQI or a commercial-AQI to a child's asthma action plan improves their asthma control. They will compare these groups to a group receiving standard asthma education. The study also aims to understand if there are changes in nasal gene expression (how genes are turned on or off in the nose) in children with asthma who are very sensitive to outdoor air pollution. To join, children need to have a diagnosis of persistent or intermittent asthma with a history of severe asthma attacks.

Study design
This is an interventional study with a planned enrollment of 351 participants. It compares different types of air quality information provided to participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants' asthma control scores will be measured at 4-week intervals from baseline through 48 weeks.

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NCT07261423

Pollution Intervention to Impact Kids Asthma Study

Recruiting
NAAges 8–17InterventionalTreatment
University of Pittsburgh
~351 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:EPA-AQICommerical-AQIEducation and plan

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in asthma control scores, over-time, between groups
Measured over Baseline through 48 weeks, measured at 4 week intervals

Conditions

Childhood Asthma
Asthma Control
Asthma Exacerbation
Air Pollution, Risk Reduction Behaviors

Explore related trials

Asthma

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Franziska Rosser, MD MPH · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Pediatric Asthma Center
[email protected]
877-296-9026
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Eligibility criteria

Inclusion

A healthcare provider diagnosis of persistent asthma (Steps 2-5 as defined by US guidelines) or intermittent asthma (Step 1) + at least one severe asthma exacerbation (defined by American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria as requiring at least 3 days of systemic steroids or an Emergency Department/Urgent Care visit requiring systemic steroids) in the prior 12 months
Home access to a smartphone or internet
Primary residence in Allegheny County, PA
One participant per household
Age 8 -17 years
Healthcare provider evaluation for asthma in the prior year

Exclusion

Diagnosis of other active chronic respiratory diseases (e.g., cystic fibrosis, bronchopulmonary dysplasia, etc.)
Neuromuscular disorder
Chronic disorder limiting independent ambulation (e.g., spastic quadriplegia, etc.)
Cyanotic heart disease
Plans to relocate from Allegheny County, PA in the next year (12 months)
Use of intranasal or oral/intramuscular/intravenous corticosteroids 4 weeks prior to randomization
Current participation in another asthma intervention trial

What this trial measures

  • Change in asthma control scores, over-time, between groupsBaseline through 48 weeks, measured at 4 week intervals

    Asthma control will be measured via the validated Asthma Control Test (ACT) and Childhood-ACT (CACT). Asthma control will be evaluated at all study visits (Visits 1-13), every 4 weeks. The ACT will be used for children aged 12 -17 years, the CACT will be used for children aged 8-11 years. The ACT is a 5 question instrument with scores from 5-25, with higher scores generally indicating better control. The CACT is a 7 question instrument with scores from 0-27, with higher scores generally indicating better control. For both ACT and CACT, scores of 19 or less are concerning for poor asthma control and both measure control in the past 4 weeks.