Pilot Study: Velopharyngeal Dysfunction in Head & Neck Cancer Survivors
This study is for head and neck cancer survivors who experience velopharyngeal dysfunction (VPD), a condition where the soft palate and back of the throat don't close properly. This can lead to nasal-sounding speech, food or liquid going into the nose, and difficulty swallowing. The study aims to better understand VPD in this group and to see if a procedure called pharyngeal wall augmentation injection can help. This injection adds a biocompatible material to the back of the throat to improve closure. You might be eligible if you are an English-speaking adult (18 or older) with a history of head and neck cancer and have nasal-sounding speech. The study will assess how well certain tools (nasometry and FEES) can identify VPD.
- Study design
- This is a prospective study with a planned enrollment of 20 participants. It uses a multidisciplinary approach to evaluate speech and swallowing function.
- What's involved
- Participants will undergo a physical exam, flexible nasolaryngoscopy, speech recording, nasometry, clinical swallowing evaluation, and fiberoptic endoscopic evaluation of swallowing (FEES). Some participants may also receive a pharyngeal wall augmentation injection.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, feasibility of nasometry and FEES, is measured at the baseline assessment. Further follow-up duration is not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Vanessa Torrecillas, MD · PRINCIPAL_INVESTIGATOR · University of Virginia
Who to contact
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What this trial measures
- Feasibility of Nasometry and FEES for Characterizing Velopharyngeal DysfunctionBaseline Assessment
Feasibility will be reported as the percentage of enrolled participants with complete, usable nasometry and FEES data at baseline. Data quality will be defined by the proportion of recordings meeting predefined technical standards for interpretation. Additional exploratory analyses will examine correlations between nasometry and FEES findings and clinical reference standards (perceptual speech ratings, SHI and SWAL-QOL scores), but correlation statistics will not be used as outcome units for feasibility reporting.