This study, called EDIT-ANDRE, is looking at how a treatment for depression works in people with unipolar or bipolar depression. Researchers want to understand if changes in RNA editing (a natural process that modifies genetic instructions) can predict how well someone responds to treatment. You would first take vortioxetine once daily for 8 weeks. If your depression doesn't improve enough, you might then add cariprazine to your treatment for another 8 weeks. The main goal is to see how much your depression symptoms improve, measured by a scale called the Montgomery-Åsberg Depression Rating Scale (MADRS). The study is recruiting 120 adults between 18 and 65 years old who have current major depressive episodes.

Study design

This is an interventional study, meaning participants will receive specific treatments. It plans to enroll 120 participants with unipolar or bipolar depression.

What's involved

You would take vortioxetine for 8 weeks. If needed, you would then add cariprazine for another 8 weeks. Your depression symptoms will be measured at several points over 16 weeks.

Compensation

Not stated in the trial record.

Follow-up

Your progress will be monitored for 16 weeks, with the last measurement at Week 16.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.