Back to search results

Pycnogenol for Gulf War Illness

This study is investigating Pycnogenol (French Maritime Pine Bark), a dietary supplement, to see if it can help reduce the severity of symptoms in people with Gulf War Illness (GWI). Researchers believe GWI involves inflammation, and Pycnogenol may help by reducing this inflammation. The study will also look at the safety of Pycnogenol and try to find the best dose. You may be able to join if you are a male, at least 18 years old, meet specific definitions for GWI, and have already participated in a previous botanical trial (NCT05377242). The study aims to measure changes in your physical and mental well-being after 12 months. The current status of this study is unclear, and it plans to enroll up to 20 participants.

Study design
This is an interventional study where participants will receive either Pycnogenol at various doses (100mg, 200mg, 400mg, or 600mg) or a placebo (an inactive substance called microcrystalline cellulose). It is a single-blind study, meaning you won't know if you're receiving Pycnogenol or the placebo. The study aims to enroll up to 20 male participants.
What's involved
You will participate for 12 months. This includes a 30-day baseline phase where you complete weekly questionnaires without taking capsules, followed by a treatment phase where you take capsules twice daily. Capsules will be mailed to you.
Compensation
Not stated in the trial record.
Follow-up
Your physical and mental functioning scores will be measured at 12 months after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07266571

Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness

Not Yet Recruiting
NAAges 18+InterventionalTreatment
University of Alabama at Birmingham
~20 participants
Updated 2026-06-17 on ClinicalTrials.gov
What's tested:PlaceboPycnogenol, 100mgPycnogenol, 200mgPycnogenol, 400mgPycnogenol, 600mg

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Physical Functioning Score of the Veterans Rand 12-Item Health Survey
Measured over 12 months
+1 more outcome measured

Conditions

Gulf War Syndrome

Explore related trials

Gulf war syndrome

NCT07266571

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Alabama at Birmingham

    Birmingham, Alabamastudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jarred Younger, PhD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

Who to contact

Jarred Younger, PhD
[email protected]
205-975-5821
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Meet the Kansas GWI case definition
Meet the CDC GWI case definition
Able to commit to a 12-month study
Male
Participants will be individuals in our Gulf War database who have already completed our other botanical trial, Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness (NCT05377242).

Exclusion

Currently involved in another experimental treatment study
Female
Have a blood clotting disorder
Reported diagnosis of diabetes with a A1C greater than 9
Use of contraindicated medications (see below):
Anticoagulants (such as warfarin, heparin, etc.)
Lithium
Tacrolimus (Prograf)
Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)
Daily Use of Antiplatelet agents (e.g. aspirin, clopidogrel)
Nitroglycerin
Hypotension
Need for surgery during study period.

What this trial measures

  • Change in Physical Functioning Score of the Veterans Rand 12-Item Health Survey12 months

    This change will be measured using weekly surveys. Veterans Rand 12-Item Health Survey scores are standardized to a mean of 50 (SD = 10), with higher scores indicating better functioning; scores theoretically range from approximately 0 to 100.

  • Change in Mental Functioning Score of the Veterans Rand 12-Item Health Survey12 months

    This change will be measured using weekly surveys. Veterans Rand 12-Item Health Survey scores are standardized to a mean of 50 (SD = 10), with higher scores indicating better functioning; scores theoretically range from approximately 0 to 100.