Emavusertib + Zanubrutinib for Chronic Lymphocytic Leukemia and Other B-cell Malignancies

This study is testing a combination of two oral medications, emavusertib and zanubrutinib, for people with chronic lymphocytic leukemia (CLL) and other B-cell malignancies (cancers that start in immune cells called B cells). The main goal is to see how well this combination works against the cancer. For some participants, success will be measured by whether the cancer cells become undetectable (undetectable measurable residual disease or uMRD). For others, success will be measured by the overall response rate (how many people have their cancer shrink or disappear). You may be able to join if you are 18 or older, have a confirmed diagnosis of CLL, and meet other health criteria. The study plans to enroll 108 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 108 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for anticancer activity for up to approximately 23 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07271667

A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies

Recruiting
PHASE2Ages 18+InterventionalTreatment
Curis, Inc.
~108 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:EmavusertibZanubrutinib

At a glance

Recruiting sites
11 of 11 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cohort 1: Undetectable Measurable Residual Disease (uMRD) Rate
Measured over Up to approximately 23 months
+1 more outcome measured
Chronic Lymphocytic Leukemia
B-cell Malignancies

NCT07271667

Where you'd take part

This study runs at 11 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Azienda Ospedale Università Padova

    Padova, Italyno site contact published

    Recruiting

  • Azienda Ospedaliero Universitaria Maggiore Della Carità

    Novara, Italyno site contact published

    Recruiting

  • Hospital Universitario Fundación Jiménez Díaz - START MADRID

    Madrid, Spainno site contact published

    Recruiting

  • IRCCS Ospedale San Raffaele

    Milan, Italyno site contact published

    Recruiting

  • Mayo Clinic

    Rochester, Minnesotano site contact published

    Recruiting

  • MD Anderson Cancer Center Madrid

    Madrid, Spainno site contact published

    Recruiting

  • Mt Sinai Comprehensive Cancer Center

    Miami Beach, Floridano site contact published

    Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohiono site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

  • Cohort 1: Undetectable Measurable Residual Disease (uMRD) RateUp to approximately 23 months
  • Cohort 2: Overall Response Rate (ORR)Up to approximately 23 months