Emavusertib + Zanubrutinib for Chronic Lymphocytic Leukemia and Other B-cell Malignancies
This study is testing a combination of two oral medications, emavusertib and zanubrutinib, for people with chronic lymphocytic leukemia (CLL) and other B-cell malignancies (cancers that start in immune cells called B cells). The main goal is to see how well this combination works against the cancer. For some participants, success will be measured by whether the cancer cells become undetectable (undetectable measurable residual disease or uMRD). For others, success will be measured by the overall response rate (how many people have their cancer shrink or disappear). You may be able to join if you are 18 or older, have a confirmed diagnosis of CLL, and meet other health criteria. The study plans to enroll 108 participants, but its current recruitment status is unclear.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 108 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for anticancer activity for up to approximately 23 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies
At a glance
Conditions
NCT07271667
Where you'd take part
This study runs at 11 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Azienda Ospedale Università Padova
Padova, Italyno site contact published
Recruiting
Azienda Ospedaliero Universitaria Maggiore Della Carità
Novara, Italyno site contact published
Recruiting
Hospital Universitario Fundación Jiménez Díaz - START MADRID
Madrid, Spainno site contact published
Recruiting
IRCCS Ospedale San Raffaele
Milan, Italyno site contact published
Recruiting
Mayo Clinic
Rochester, Minnesotano site contact published
Recruiting
MD Anderson Cancer Center Madrid
Madrid, Spainno site contact published
Recruiting
Mt Sinai Comprehensive Cancer Center
Miami Beach, Floridano site contact published
Recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohiono site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Cohort 1: Undetectable Measurable Residual Disease (uMRD) RateUp to approximately 23 months
- Cohort 2: Overall Response Rate (ORR)Up to approximately 23 months