Study of Elamipretide for Healthy Aging and Physical Function

This study is looking at a drug called elamipretide in healthy adults aged 65 to 80. The main goal is to see if daily injections of elamipretide are safe and well-tolerated over 4 weeks. Researchers will also look at changes in inflammation markers in the blood and how it might affect physical function. You might be able to join if you are 65-80 years old, can walk on your own, and have certain levels of mitochondrial function (VO2peak). The study plans to enroll 30 participants. The current status of the study is unclear, so it's not known if they are actively recruiting.

Study design
This is a Phase 2a, open-label (meaning you and the study staff will know what treatment you are receiving), single-arm study involving 30 older adult participants.
What's involved
You would have baseline measurements, receive daily subcutaneous (under the skin) injections of elamipretide for 4 weeks, have a phone interview at 2 weeks, and attend post-intervention visits.
Compensation
Not stated in the trial record.
Follow-up
After the last injection, participants will enter a 2-week follow-up period, ending with a final contact.

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NCT07275424

Study of Healthy Aging and Physical Function With Elamipretide

Recruiting
PHASE2Ages 65–80InterventionalTreatment
David Marcinek
~30 participants
Updated 2025-12-10 on ClinicalTrials.gov
What's tested:Elamipretide will be supplied as a sterile 5.0 mL single-patient, multi-dose glass vial containing 3.75 mL of elamipretide solution (elamipretide [80 mg/mL], phosphate buffer, and benzyl alcohol)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To evaluate the safety and tolerability of daily subcutaneous injections of elamipetide: Number of participants with treatment-related adverse events and Number of participants completed 4 weeks of injection
Measured over 4 week
Aging, Healthy
1 sites across 1 states
Washington1
  • David Marcinek, PhD · PRINCIPAL_INVESTIGATOR · University of Washington

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Eligibility criteria

Inclusion

Coenzyme Q10, creatine, L-carnitine, and other supplements intended to increase muscle mass, energy or function
Muscle relaxants
Systemic steroid or immunosuppressive use
Opioids (regular use of \> 10 mg/day morphine equivalents) 9. No known allergies/adverse effects from Fexofenadine 10. Provide documentation of informed consent
  • To evaluate the safety and tolerability of daily subcutaneous injections of elamipetide: Number of participants with treatment-related adverse events and Number of participants completed 4 weeks of injection4 week