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Organic Whole Psilocybin-Containing Mushrooms for PTSD

This study is looking at whether organic whole psilocybin-containing mushrooms are safe and helpful for adults with Post-Traumatic Stress Disorder (PTSD). Up to 24 people will take part. You might be able to join if you are at least 18 years old and have been diagnosed with PTSD for at least six months. Participants will take psilocybin from dried mushrooms in a chocolate form. Researchers will be watching closely for any side effects and mental health changes for three months after you take the mushrooms to see if the treatment is safe and if it helps with PTSD symptoms. The study's current status is unclear.

Study design
This is an interventional study with a planned enrollment of 24 participants. It will examine the safety and preliminary effectiveness of the treatment.
What's involved
You will ingest psilocybin from dried mushrooms in a chocolate formulation. Researchers will monitor you for adverse events and mental/psychotic adverse events from dosing to a 3-month follow-up.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for adverse events and mental/psychotic adverse events for three months after dosing.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07275970

Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD

Active, Not Recruiting
PHASE1Ages 18+InterventionalTreatment
Scottsdale Research Institute
~24 participants
Updated 2026-07-29 on ClinicalTrials.gov
What's tested:Psychedelic

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number/Incidence of adverse events (AEs), and serious adverse events (SAEs) graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
Measured over From dosing to 3-month follow-up
+1 more outcome measured

Conditions

PTSD

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

1 sites across 1 states
Arizona1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Meet Diagnostic and Statistical Manual-5th edition (DSM-5) criteria for current PTSD with a duration of 6 months or longer as assessed by a study psychiatrist.
Determination of at least one traumatic event as determined by the LEC-5
A score of at least 33 on the PCL-5 3. Willing and able to provide signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

What this trial measures

  • Number/Incidence of adverse events (AEs), and serious adverse events (SAEs) graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.From dosing to 3-month follow-up
  • Number/Incidence of Mental and Psychotic AE'sFrom dosing to 3-month follow-up