Ketamine for Phantom Limb Pain Outpatient Treatment
This study is exploring if ketamine, given as an injection, can help treat phantom limb pain (pain felt in a body part that is no longer there). Researchers are looking for 25-30 adults, aged 18-65, who have ongoing significant phantom limb pain. You must live within 50 miles of study sites in the Bay Area, Los Angeles, Albuquerque, or Sacramento. The study will look at how much your pain improves over six months, with a follow-up for a year. Success will be measured by changes in your pain levels using a special questionnaire. This study is currently open for enrollment.
- Study design
- This is an interventional study planning to enroll 25-30 participants. It will involve intermittent ketamine treatment, with the dose adjusted based on your response.
- What's involved
- You would participate in the study and follow-up over a year-long period. This includes receiving ketamine injections and completing pain questionnaires.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will have a 12-month follow-up after the 6-month treatment period.
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NCT07276542
Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved.
Recruiting
PHASE2Ages 18–65InterventionalTreatmentThe Ketamine Research FoundationInvestigator-initiated
~30 participants
Updated 2026-03-18 on ClinicalTrials.gov
What's tested:IM ketamine in dose finding and then continuation
At a glance
Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
McGill Pain Questionnaire SF-MPQ-2
Measured over 6 months per subject with a 12 month follow-up
Conditions
NCT07276542
Where you'd take part
This study runs at 4 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Ketamine Research Foundation
San Anselmo, Californiastudy coordinator listed
Recruiting
Lisa Feierman MD
Albuquerque, New Mexicostudy coordinator listed
Recruiting
Mystic Health
Santa Monica, Californiastudy coordinator listed
Recruiting
Shamynds
Sacramento, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Eligibility criteria
Inclusion
Presence of phantom limb pain at the time of administration of ketamine.
Willingness to participate in the study and follow-up over a year long period. Living Within a 50 mile radius of our study sites: Bay Area, Los Angeles, Albuquerque, Sacramento, Los Angeles
Provision of signed and dated, written informed consent prior to any study-specific procedures.
If female, must have a negative pregnancy test at Screening and any subsequent administration of ketamine. Sexually active females and male partners must be using adequate birth control measures during the duration of the study when ketamine will be administered and for one week after the last administration of ketamine.
Patient agrees to withhold alcohol, marijuana, nicotine products, and any other intoxicants for at least 24 hours
Normotensive-defined as Abnormal VS, after 5 minutes supine rest at Screening or on Day -1, defined as any of the following:
Diastolic BP\> 105 mmHg.
HR \<50 or \>110 bpm.
Not on Medications that would blunt ketamine's effects
18-65
No prior history of treatment with ketamine for PLP.
Exclusion
History of any clinically important disease or disorder which, in the opinion of the Investigator, may either put the patient at risk because of participation in the study, or influence the results or the patient's ability to participate in the study.
Vulnerable persons are Excluded from the study. This includes subjects with known psychotic illness, mania, significant neurologic disorders, elevated intraocular and or intracranial pressures
Exclusion of subjects with abnormal baseline hepatic and renal lab tests.
Exclusion of subjects with cardiovascular disease, arrythmias, or abnormal EKGs.
The presence of any medication that might cause an adverse reaction with ketamine.
The Ketalar Label as cited by FDA includes Drug Interactions particular to anesthesia and the use of IV boluses at far higher dosages than those used in our study. In Review of these:
Sympathomimetics And Vasopressin-Excluded
Benzodiazepines-PLP patients may be on benzodiazepines or other anxiolytic medications, Subjects will be asked to suspend daytime use of these whenever possible recognizing that anxiety is an often present symptom within the PLP complex. Recognition of a possible increase in sedation due to the concomitant presence of a benzodiazepine with ketamine may lead to a lowering of the ketamine dosage. Nighttime use of a benzodiazepine for treatment of insomnia will not be discontinued unless the dosage is high and considered to have a sedating effect on the degree of ketamine's sedation the next day. The length of time between nighttime use and administration of ketamine during the day should diminish the effects of the nighttime medication.
Opioid Analgesics -PLP subjects most likely will have been or will be receiving opiates for pain relief, Concomitant use of ketamine and opiates in outpatient settings for analgesia is a common and accepted practice. Withdrawing opiates for ketamine administered in subanesthetic doses is not appropriate. In several studies ketamine has been shown to reduce the amount of opioids needed for analgesia, It is the hope of this study that successful treatment with ketamine will enable reduction or cessation of opioid use, In our vast clinical experience, we have treated with ketamine at subanesthetic doses patients on opiates without adverse effects.
Subjects on long-acting opioids such as methadone or extended-release opioids are excluded.
Subjects with opioid use 50 mg/day MME (morphine milliequivalents) within 1 week of initial ketamine administration are excluded.
Subjects with +UDS (urine drug screen) for ketamine, cocaine, methamphetamine, PCP, or other substances of abuse are excluded.
Subjects who have used THC may be enrolled but must have abstained from THC for at least 3 days prior to each ketamine session
Oral IR (immediate release) opioid mu agonists up to 50 mg/day MME (morphine milliequivalents) are allowed (e.g., hydromorphone, oxycodone, morphine, and hydrocodone).
No increases of any opioids or other concomitant medications, or addition of new medications or therapies for PLP will be allowed during the study.
All concomitant medications, including type and amount, will be recorded by study participants in their daily diaries and reviewed by study staff before each treatment session and any scheduled telephone calls.
Participants will not receive opioids 4 hours before or after ketamine administration.
Laboratory assessments: Subjects with abnormal baseline hepatic or renal lab tests are to be excluded. In addition, obtain the following laboratory tests at the following times: CBC, hepatic and renal labs at 3 months and 6 months. Follow-up abnormal laboratory values.
Or Other CNS Depressants-gabapentin may well be prescribed for patients with PLP as is true for pregabalin, Whenever possible subjects will be asked to withhold these for at least 4 hours prior and not resume for at least 4 hours after the last administration of ketamine. This is consistent with two half-lives of ketamine
Alcohol-Daily use exceeding 2 US Standard drinks. No alcohol use in 24 hours preceding a ketamine session.
Stimulants-Subjects will be asked to withhold stimulants for 5-12 hours prior to administration of ketamine depending on the duration of action of the particular preparation and not resume until the next day after treatment.
What this trial measures
- McGill Pain Questionnaire SF-MPQ-26 months per subject with a 12 month follow-up
A complex assassement measure for complex pain presentations