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NCT07279350

Health Advocate for Children After Liver Transplant

Recruiting
NAAges 0–18InterventionalHealth services
University of California, San Francisco
~108 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Health advocateEnhanced Control

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time-to-TCMR between 90 days and 2 years post-transplant using Kaplan-Meir plots.
Measured over Through study completion, an average of 1 year up to 2 years.

Conditions

Pediatric Liver Transplanted Recipients

Explore related trials

Liver Transplantation

Where it's being run

2 sites across 2 states
California1
Pennsylvania1

Study leadership

  • Sharad Wadhwani, MD, MPH · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Bethany Reyna, BA, CCRP
[email protected]
415-476-7748
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient \<18 years old at the time of liver transplant
Received a liver transplant within past 90 days
Family endorses material economic hardship on 10-questions Accountable Healthcare Communities screening tool.
Will receive follow-up care for at least 2 years
Family can read or write English or Spanish
A Legally Authorized Representative (LAR) can provide consent, and for children (12-17 years of age, the child is willing/able to provide assent.)
Family has a working phone and smartphone device capable of receiving calls or virtual visits via Zoom.

Exclusion

Patient has severe cognitive impairment.
18 years of age or older at the time of consent
Patient unwilling or unable to consent/participate
Patient is a ward of the state (e.g. foster care) since present circumstances may not be reflective of child's past or future circumstances.
Non-English, non-Spanish speakers as ICFs, HIPAA authorization form, surveys, and interviews will only be available in these 2 languages. Languages besides English and Spanish are excluded from this study.

What this trial measures

  • Time-to-TCMR between 90 days and 2 years post-transplant using Kaplan-Meir plots.Through study completion, an average of 1 year up to 2 years.

    After the perioperative period, it is an objective outcome closely linked with poor adherence/challenges with self-management. Investigators found strong associations between material economic hardship and TCMR episodes of TCMR increase risks of graft failure/death post-transplant and early TCMR increases risk of late TCMR and vulnerability to infections. All analyses will be intention-to-treat. Investigators will use Kaplan-Meier plots to descriptively compare survival distributions of the primary outcome (TCMR) by trial arm. We will compare time-to-TCMR between treatment arms using Cox regression. For participants recruited in years 1 \& 2 of the study period, we will collect 2 years of follow-up data. For participants recruited in year 3, we will apply administrative censoring after 1 year of follow up data.