Acute Pulmonary Embolism Treatment with AlphaVac and AlphaReturn Systems

This study is testing the safety and effectiveness of the AlphaReturn Blood Management System when used with the AlphaVac Multipurpose Mechanical Aspiration System. These devices are used to treat acute pulmonary embolism (blood clots in the lungs). You may be able to join if you are 18 or older and have symptoms of an acute intermediate-risk pulmonary embolism that started within the last 14 days. The study will look at how often device-related problems occur within 30 days after the procedure and how successful the procedure is. The current recruitment status is unclear, and the study plans to enroll 39 participants.

Study design
This is a single-arm study, meaning all participants receive the same treatment. It is an investigational device study evaluating safety and effectiveness.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for device-related adverse events through 30 days post-procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07280247

Acute Pulmonary Embolism Treatment With the AlphaVac Multipurpose Mechanical Aspiration System and the AlphaReturn Blood Management System: Evaluation of Safety and Effectiveness

Recruiting
NAAges 18+InterventionalTreatment
Angiodynamics, Inc.
~39 participants
Updated 2026-05-11 on ClinicalTrials.gov
What's tested:AlphaReturn Blood Management System

At a glance

Recruiting sites
6 of 6 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of Device-Related Adverse Events (AEs)
Measured over Through 30 days post-procedure
+1 more outcome measured
Pulmonary Embolism Acute

NCT07280247

Where you'd take part

This study runs at 6 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Baylor Heart Hospital Plano

    Plano, Texasstudy coordinator listed

    Recruiting

  • CentraCare Heart and Vascular Center

    Saint Cloud, Minnesotastudy coordinator listed

    Recruiting

  • Jacobi Medical Center

    The Bronx, New Yorkstudy coordinator listed

    Recruiting

  • Kettering Health

    Kettering, Ohiostudy coordinator listed

    Recruiting

  • Methodist Healthcare

    San Antonio, Texasstudy coordinator listed

    Recruiting

  • University at Buffalo

    Buffalo, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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  • Rate of Device-Related Adverse Events (AEs)Through 30 days post-procedure

    The number and proportion of subjects who experienced at least one device-related adverse event. This will be summarized, and the 95% confidence interval of the proportion will be presented. The incidence of device-related adverse events by type and seriousness through 30 days will also be summarized.

  • Rate of Technical SuccessPeriprocedural

    Successful autologous blood transfusion using the AlphaReturn Blood Management System