Intercostal Cryoanalgesia for Post-Operative Pain After Double Lung Transplant

This study is exploring a new approach to manage pain after a double lung transplant. Doctors will use a cold-therapy probe, called the Atricure CryoSPHERE MAX Probe, during surgery to gently freeze nerves near the incision. This aims to reduce pain and potentially lower the need for strong pain medications (opioids) after your surgery. You may be eligible if you are an adult (18 years or older) undergoing a double lung transplant. The main goal is to see if this treatment can reduce the total amount of opioids you need in the first year after surgery. The study's current status is unclear, and it plans to enroll 148 participants.

Study design
This is an interventional study planning to enroll 148 participants. It compares patients receiving the Atricure CryoSPHERE MAX Probe to those receiving usual care.
What's involved
Patients will receive the Atricure CryoSPHERE MAX Probe treatment during their double lung transplant procedure. They will be followed for one year after their transplant.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year after their transplant procedure.

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NCT07281118

Intercostal Cryoanalgesia in Double Lung Transplant Recipients

Recruiting
NAAges 18+InterventionalSupportive care
University of California, Los Angeles
~148 participants
Updated 2026-03-05 on ClinicalTrials.gov
What's tested:Atricure CryoSPHERE MAX Probe

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total opioid use (oral morphine equivalents)
Measured over 1 year
Post-operative Pain Management
3 sites across 2 states
California2
Texas1
  • Abbas Ardehali, MD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles

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Eligibility criteria

Inclusion

Adults ≥18 years of age
Undergoing double lung transplantation via bilateral thoracotomies or clamshell incision

Exclusion

Multi-organ transplant recipients
Redo lung transplant recipients
  • Total opioid use (oral morphine equivalents)1 year

    Total opioid use (oral morphine equivalents)