Trial of ONC-PluReceptor NK Cells for B-cell Non-Hodgkin Lymphoma

This study is testing a new treatment for people with B-cell Non-Hodgkin Lymphoma that has come back (recurrent) or hasn't responded to other treatments (refractory). The treatment involves special immune cells called ONC-PluReceptor NK cells, given by injection, along with two other medicines called epcoritamab and tafasitamab. Researchers want to see if this combination can help control the lymphoma and how safe it is. You might be able to join if you are 18-80 years old, have B-cell Non-Hodgkin Lymphoma that has failed at least two prior treatments or a stem cell transplant, and your tumor shows specific markers (CD19 or CD20). The study aims to enroll 30 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 30 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your safety will be monitored throughout the study completion, which is an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07283679

Trial of ONC-PluReceptor NK Cells With Epcoritamab and Tafasitamab for Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma

Recruiting
PHASE1Ages 18+InterventionalTreatment
M.D. Anderson Cancer Center
~30 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:ONC-PluReceptor NK cells

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety and Adverse Events (AEs)
Measured over Through study completion; an average of 1 year.
Recurrent B-Cell Non-Hodgkin Lymphoma
Refractory B-cell Non-Hodgkin Lymphoma
1 sites across 1 states
Texas1
  • Yago Nieto, MD,PHD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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  • Safety and Adverse Events (AEs)Through study completion; an average of 1 year.

    Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0