A Study of Buntanetap in Participants With Parkinson's Disease

This study is looking at the long-term safety of a drug called buntanetap in people with Parkinson's Disease (PD). It will last for 36 months (3 years). There are two groups of participants: one group includes people who have already taken part in buntanetap studies, and the other group includes people with PD who are receiving deep brain stimulation (DBS) treatment. The main goal is to see how safe buntanetap is by tracking any side effects over this long period. The study aims to enroll 500 participants aged 40 to 85 years old. The current recruitment status is unclear.

Study design
This is an open-label safety study, meaning both you and the study team will know you are receiving buntanetap. It plans to enroll 500 participants.
What's involved
You would take buntanetap capsules 30 mg by mouth daily after a screening period of up to 42 days. The study will last for 36 months, with regular assessments.
Compensation
Not stated in the trial record.
Follow-up
The primary safety outcomes are measured at 36 months of treatment.

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NCT07284784

A Study of Buntanetap in Participants With PD

Recruiting
PHASE2Ages 40–85InterventionalTreatment
Annovis Bio Inc.
~500 participants
Updated 2026-07-21 on ClinicalTrials.gov
What's tested:buntanetap/posiphen

At a glance

Recruiting sites
26 of 27 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety of buntanetap
Measured over 36-months of treatment
+3 more outcomes measured
Parkinson's Disease (PD)
Deep Brain Stimulation

NCT07284784

Where you'd take part

This study runs at 27 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Abington Neurology

    Willow Grove, Pennsylvaniastudy coordinator listed

    Recruiting

  • Accel Clinical Sites-Georgia LLC dba Accel Research Sites-Lake Oconee CRU

    DeLand, Floridastudy coordinator listed

    Recruiting

  • Arrow Clinical Trials

    Daytona Beach, Floridastudy coordinator listed

    Recruiting

  • Banner Sun Health Research Institute - Cleo Roberts Center for Clinical Research

    Sun City, Arizonastudy coordinator listed

    Recruiting

  • Cenexel Rocky Mountain Clinical Research

    Englewood, Coloradostudy coordinator listed

    Recruiting

  • Central Texas Neurology

    Round Rock, Texasstudy coordinator listed

    Recruiting

  • Conquest Research

    Winter Park, Floridastudy coordinator listed

    Recruiting

  • Duke Department of Neurosurgery

    Durham, North Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Laurie Sanders, Ph.D. · PRINCIPAL_INVESTIGATOR · Duke Clinical Research Institute

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Eligibility criteria

Inclusion

Non-childbearing potential includes surgically sterilized or postmenopausal with no menstrual bleeding for at least one year prior to study start.
Silicified microcrystalline cellulose
Dibasic calcium phosphate dihydrate
Mannitol
Stearic acid
Hypromellose (capsule shells structure)
Titanium dioxide (opacifier of the capsule shells) 16. Is currently pregnant, breast-feeding, and/or lactating. 17. Uncontrolled hypertension (systolic \>160mmHg and/or diastolic \>95mmHg) or hypotension (systolic \<90mmHg and/or diastolic \<60 mmHg) and deemed medically significant by the PI.
  • Safety of buntanetap36-months of treatment

    Safety assessments of participants with PD receiving treatment with buntanetap

  • Adverse Events (AE)36-months of treatment

    An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of a study intervention, whether or not considered related to the study intervention

  • Treatment Emergent Adverse Events (TEAE)36-months of treatment

    TEAE is an event that emerges during treatment, having been absent pretreatment, or worsens relative to the pretreatment state

  • Serious Adverse Events (SAE)36-months of treatment

    SAE is defined as any untoward medical occurrence that results in death, is life-threatening, requires inpatient hospitalization, or prolongation of an existing hospitalization, results in persistent or significant disability or incapacity, is a birth defect or congenital anomaly