Cancer Connected Access and Remote Expertise (CARE) Beyond Walls Program

This study, called the Cancer Connected Access and Remote Expertise (CARE) Beyond Walls (CCBW) program, is looking at whether receiving your standard cancer treatment at home is preferred over going to a clinic. It also wants to see if home treatment makes patients more satisfied. You might be able to join if you are an adult cancer patient in the Florida Panhandle or surrounding areas, are receiving a standard cancer treatment, and your doctor believes you can tolerate it well. The study aims to understand patient preferences for treatment location and track any side effects related to where you receive treatment. We are also looking at how many urgent care, emergency room, or hospital visits happen. The study plans to enroll 27 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment or procedure. It plans to enroll 27 participants.
What's involved
Participants will either receive their standard of care cancer treatment at home or in the clinic. They will also complete questionnaires.
Compensation
Not stated in the trial record.
Follow-up
Patient preferences will be measured at 12 weeks. Adverse events will be tracked for up to 9 months, and acute care visits for up to 24 weeks.

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NCT07285044

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Recruiting
PHASE2Ages 18+InterventionalTreatment
Mayo Clinic
~27 participants
Updated 2026-07-30 on ClinicalTrials.gov
What's tested:Cancer Therapeutic ProcedureQuestionnaire Administration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient preferences regarding location of cancer treatment delivery
Measured over At 12 weeks
+2 more outcomes measured
Amyloidosis
Basal Cell Carcinoma
Biliary Tract Carcinoma
Bladder Carcinoma
Breast Carcinoma
Cervical Carcinoma
Colorectal Carcinoma
Endometrial Carcinoma
Fallopian Tube Carcinoma
Gastroesophageal Junction Carcinoma
Glioblastoma
Head and Neck Carcinoma
Hematopoietic and Lymphatic System Neoplasm
Hepatocellular Carcinoma
Hodgkin Lymphoma
Lung Carcinoma
Malignant Solid Neoplasm
Mantle Cell Lymphoma
Melanoma
Merkel Cell Carcinoma
Multiple Myeloma
Myelodysplastic Syndrome
Ovarian Carcinoma
Pancreatic Carcinoma
Primary Peritoneal Carcinoma
Prostate Carcinoma
Renal Cell Carcinoma
Squamous Cell Carcinoma
Urothelial Carcinoma
1 sites across 1 states
Florida1
  • Roxana S. Dronca, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Patient has had adequate tolerability of their clinical standard of care treatment, in the opinion of their treating physician, and no clinically significant drug-related reactions occurred prior to consent
Participant must be receiving a standard-of-care treatment regimen listed in this protocol that is being used in accordance with standard medical practice. Specifically, it must be either a) Food and Drug Administration (FDA)-approved for the participant's disease indication, or b) recommended in nationally recognized professional guidelines (e.g. National Comprehensive Cancer Network \[NCCN\], American Society of Clinical Oncology \[ASCO\], American Society of Hematology \[ASH\], etc.) as standard of care for the disease indication. Off-label use is permitted only if supported by such guidelines
A social stability screener, used per standard of care, indicates patient is appropriate to participate in the CCBW program
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, 2 or 3 at the discretion of the treating physician
Female or male patients age \>= 18 years at the time of consent
Willing and able to comply with the study protocol in the investigator's judgement
Patients with histologically confirmed malignancy who are currently receiving treatment with one of the eligible treatment regimens. Patients with hepatocellular carcinoma (HCC) are eligible based on imaging diagnosis alone: histologic confirmation is not required.
Note: patients diagnosed with any of the following disease types may receive any of the eligible regimens listed. Additionally, patients receiving hormonal or immunotherapy, such as nivolumab or pembrolizumab, may receive these infusions in home supplemental to any of the regimens identified. Co-administration with hormonal agents such as anti-androgens, poly(ADP-ribose) polymerase (PARP) inhibitors, oral gonadotrophin releasing hormone (GnRh) antagonists, estrogens, selective estrogen receptor modulators (SERMs), or aromatase inhibitors are allowed, however combinations of oral regimens only are not permitted. Patients may receive any combination of any listed medications or regimens
Eligible disease cancer types:
Amyloidosis
Basal cell carcinoma
Biliary
Bladder
Breast
Cervical
Colorectal
Endometrial
Fallopian tube
Gastroesophageal
Glioblastoma
Head and neck
Hepatocellular
Hodgkin lymphoma
Lung
Mantle cell lymphoma
Merkle cell carcinoma
Multiple myeloma
Melanoma
Myelodysplastic syndrome
Ovarian
Pancreatic
Peritoneal
Prostate
Renal cell carcinoma
Squamous cell carcinoma
Urothelial carcinoma
Eligible regimens
Atezolizumab +/- bevacizumab
Avelumab
Bevacizumab
Bortezomib
Cemiplimab
Daratumumab +/- bortezomib
Darbepoetin alpha
Degarelix
Denosumab (Xgeva)
Durvalumab
Fluorouracil +/- bevacizumab
Fulvestrant
Goserelin
Ipilimumab +/- Nivolumab
Lanreotide
Leuprolide
Nivolumab
Nivolumab + relatlimab
Octreotide
Pembrolizumab
Pertuzumab +/- trastuzumab
Trastuzumab +/- pertuzumab
Zoledronic acid (Zometa)
Willingness to follow birth control requirements for females and males of reproductive potential
Resides within the Florida Panhandle and surrounding area serviced by the at-home healthcare supplier utilized for the study and a paramedic network
Patient's residence has an existing Wi-Fi connection or can be connected using using a mobile Wi-Fi device provided as part of the program so as to enable a reliable connection with the remote CCBW Command Center at Mayo Clinic
Patients who, according to documentation from their treating provider, plan to continue the eligible treatment regimen they are currently prescribed for \>= 12 weeks from the time of registration
Provide written informed consent
Ability to complete questionnaire(s) by themselves or with assistance
Willing to return to enrolling institution for follow-up (during the Active Monitoring Phase of the study)

Exclusion

Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
Receiving any investigational agent which would be considered as a treatment for the primary neoplasm.
Note: oral concomitant medications for oncologic indications will be maintained per standard of care treatment and not considered part of the trial. Any nononcologic medication, regardless of route of administration will be maintained per standard of care treatment and also not considered part of the trial; therefore, patients receiving oral anti-cancer or other medications per standard of care treatment in addition to any of the medications listed are considered eligible for this trial
Individuals who require continuous (24/7) assistance with daily living and are unable to independently manage the technology required for study participation, unless a caregiver is available and willing to provide consistent support throughout the study
Current inpatient hospitalization (excluding admission to the Advanced Care at Home program)
  • Patient preferences regarding location of cancer treatment deliveryAt 12 weeks

    As assessed by a single item asking patients to rate their preferred location for cancer treatment delivery on a 1 to 7 scale: 1 = strongly prefer in clinic, 2 = moderately prefer in clinic, 3 = slightly prefer in clinic, 4 = no preference, 5 = slightly prefer at home, 6 = moderately prefer at home, 7 = strongly prefer at home. Patients who receive any care in the mobile unit will be instructed to consider "at home" to mean receipt of care inside their home or near their home in the mobile unit.

  • Adverse Events Related to Location of TreatmentUp to 9 months

    Safety of at-home administration of cancer treatment will be assessed by incidence of grade 3+ adverse events at least possibly related to the location of cancer treatment delivery that occur up to 30 days after the administration of the last dose of study drug/agent or therapy. The maximum grade for each type of adverse event will be summarized using Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

  • Incidence of avoidable acute care visits, emergency room visits, and hospitalizationsUp to 24 weeks

    Safety of at-home administration of cancer treatment will be assessed by the frequency and proportion of patients who experience an avoidable (in the opinion of the treating physician) acute care visit, emergency room visit, or hospitalization while receiving at-home cancer treatment.