This study is looking at whether a cream called topical 5% niacinamide can help prevent skin cancer in people who have received an organ transplant. Organ transplant recipients have a higher risk of skin cancer because of the medications they take to prevent organ rejection. While sunscreen is important, researchers are exploring other ways to protect the skin. Early research suggests niacinamide might be helpful. This trial will see if applying topical 5% niacinamide daily to sun-exposed areas, along with daily sunscreen, can reduce the number of precancerous growths called actinic keratoses (AKs). You might be able to join if you are an adult organ transplant recipient with a history of at least five AKs or prior skin cancer, and are willing to use SPF30 sunscreen.

Study design

This is a randomized controlled trial, meaning participants will be assigned to different groups by chance. The study plans to enroll 20 participants.

What's involved

Participants will apply topical 5% niacinamide daily to sun-exposed areas and use SPF30 sunscreen daily. Your actinic keratosis (AK) count will be measured at the beginning of the study, and again at 6 months and 12 months.

Compensation

Not stated in the trial record.

Follow-up

Your actinic keratosis (AK) count will be measured at 6 months and 12 months after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.