Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness

This study is looking at how using a special ultrasound score, called VExUS (Venous Excess Ultrasound), can help doctors manage fluids in critically ill patients in the ICU who have acute kidney injury (AKI). You would be in one of two groups: one where your care team gets recommendations based on your VExUS score for fluid management, or another where they don't. The study aims to see if using VExUS to guide fluid balance (how much fluid you receive or lose) can improve important outcomes like survival, the need for kidney dialysis (renal replacement therapy), and long-term kidney function. We are looking for 100 adult patients who are in the ICU with AKI.

Study design
This is an interventional study with 100 participants, combining observational and randomized components. It compares two groups: one where doctors receive VExUS recommendations and one where they do not.
What's involved
You would undergo two VExUS ultrasound assessments: one at enrollment and another 48-72 hours later. Blood tests and fluid balance records would also be collected.
Compensation
Not stated in the trial record.
Follow-up
Your in-hospital mortality, need for renal replacement therapy, and persistent renal dysfunction will be measured for up to 30 days.

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NCT07291778

Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness

Not Yet Recruiting
NAAges 18+InterventionalTreatment
University of Alabama at Birmingham
~100 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Fluid ManagementNo intervention

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
In-hospital Mortality
Measured over up to 30 days
+2 more outcomes measured
Acute Kidney Injury
VExUS
1 sites across 1 states
Alabama1

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Eligibility criteria

Inclusion

Adults (≥18 years old)
Admitted to the MICU, MCCU, or CCU within 24 hours of admission
Acute kidney injury (AKI) (based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria)
Adequate acoustic windows for a complete VExUS scan

Exclusion

\< 18 years old
pregnant women
End-stage renal disease (ESRD) or prior renal transplant
Acute tubular necrosis (ATN) defined by urinalysis (≥2+ protein, ≥2+ blood, ≥1 muddy brown cast, ≥1 RBC cast, or ≥1 dysmorphic RBC)'
Prior Whipple procedures
currently incarcerated
  • In-hospital Mortalityup to 30 days

    In-hospital mortality: Death from any cause before hospital discharge, within the 30-day window.

  • Renal Replacement Therapyup to 30 days

    New receipt of Renal Replacement Therapy (RRT): Receiving dialysis or another form of RRT for the first time.

  • Persistent Renal Dysfunctionup to 30 days

    Persistent renal dysfunction: The final serum creatinine value before hospital discharge (within 30 days) is 200% (twice) or more of the patient's baseline creatinine value.