Comparing Drospirenone and Norethindrone for Postpartum High Blood Pressure

This study is looking at two different progestin-only birth control pills, norethindrone and drospirenone, to see how well they help manage high blood pressure (hypertension) after delivery in women who had preeclampsia. Preeclampsia is a serious condition during pregnancy that causes high blood pressure. You might be able to join if you recently gave birth at Oregon Health & Science University (OHSU), had preeclampsia, and are thinking about using a progestin-only birth control pill. The main goal is to see how your blood pressure changes over six weeks after delivery while taking one of these medications. The study is currently unclear on its recruitment status and plans to enroll 50 participants.

Study design
This is an open-label, randomized study, meaning you and your doctors will know which medication you are taking. About 50 participants will be randomly assigned to receive either norethindrone or drospirenone.
What's involved
You would take one pill daily from hospital discharge until six weeks postpartum. You would also receive weekly emails to report medication use, home blood pressure readings, and any changes in your health or medications.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for six weeks after delivery to monitor their blood pressure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07293728

A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Oregon Health and Science University
~50 participants
Updated 2025-12-19 on ClinicalTrials.gov
What's tested:Norethindrone 0.35 MGDrospirenone

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blood Pressure
Measured over Measured weekly for the 6 weeks following delivery.
Hypertension
Preeclampsia
1 sites across 1 states
Oregon1
  • Julia Tasset · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University
Women's Health Research Unit Department of OB/Gyn
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Admission to Oregon Health \& Science University following a birth (during the same admission)
A diagnosis of preeclampsia or chronic hypertension with superimposed preeclampsia (with or without severe features)
Considering use of a progestin-only pill for postpartum contraception

Exclusion

Planned use of a contraceptive method other than a progestin-only pill
Contraindications to drospirenone or norethindrone
Inability to monitor blood pressure at home after discharge
Inability to complete follow-up surveys by email in English
  • Blood PressureMeasured weekly for the 6 weeks following delivery.

    Arterial, systolic, and diastolic blood pressure will be compared between norethindrone and drospirenone users. Measured by participants at home and reported in weekly surveys.