Ketamine and Propofol NeuroImaging Study
This study is looking at how the commonly used anesthetic medicines, ketamine and propofol, affect your brain activity, brain connections, memory, and pain. Researchers will give you these medicines alone and in combination, and then take pictures of your brain (MRI) and measure brain waves (EEG). They want to see how well you remember things and how you rate pain after receiving these drugs. The study is looking for 60 adults between 18 and 59 years old who do not have certain health conditions like chronic pain or sleep apnea. The goal is to understand how these drugs work in the brain for memory and pain.
- Study design
- This interventional study plans to enroll 60 participants. It compares the effects of ketamine and propofol, both alone and in combination, on brain activity and memory.
- What's involved
- You would attend 8 visits, each spaced at least one week apart. Four visits involve receiving drugs and having EEG or MRI scans, lasting 3 hours. The other four visits are for memory testing the day after a drug session, lasting 1 hour.
- Compensation
- Not stated in the trial record.
- Follow-up
- Memory performance is measured up to 12-36 hours after drug administration, and pain ratings are taken immediately after each experimental condition.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Ketamine and Propofol NeuroImaging
At a glance
Conditions
NCT07294092
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Pittsburgh
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Keith M Vogt, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Explicit Memory Performance, comparing single-drug to drug-combination conditionVisits 2, 4, 6, and 8. Visits spaced at least 1 week apart, are 1 hour in length, and are 12-36 hours after the preceding visit (1, 3, 5, and 7).
Recognition memory testing, using the Remember-Know procedure, in which subjects indicate whether they recognize previously experienced experimental items among novel items (not previously in the experiment). This allows calculation of interdependent measures of recollection \& familiarity using the signal detection statistic, d'. d' is calculated as the cumulative Gaussian distribution of false positive responses subtracted from the cumulative Gaussian distribution of correctly identified previously-experienced items. d' is on a (theoretically infinite) scale of standard deviation units, with negative values representing performance worse than chance guessing and positive values representing stand deviations of performance above chance.
- Pain intensity and unpleasantness ratings, comparing single-drug to drug-combination conditionVisits 1, 3, 5, and 7: immediately following each experimental condition. These visits are 3 hours in length and spaced at least 1 week apart.
Numerical rating scale (0-10) pain score difference, comparing the single-drug condition to the steady-state dose of the drug-combination condition. Higher pain scores indicate more pain; a positive difference between pain scores during the single-drug condition minus the value during the steady-state dose of the combination-drug condition indicates pain reduction (a better outcome).