Arestin-Enhanced SRP for Periodontitis and Diabetes

This study is looking at how adding Arestin (minocycline microspheres), a local antibiotic, to a common dental cleaning procedure called Scaling and Root Planing (SRP) affects people with type 2 diabetes and gum disease (periodontitis). Researchers want to see if this combination treatment helps close gum pockets, improves blood sugar control, and reduces overall body inflammation. You might be able to join if you are an adult (18 or older) with type 2 diabetes (HbA1c between 7.0% and 9.5%) and moderate to severe periodontitis. You also need at least 16 teeth and no recent gum treatment. The study aims to enroll 42 participants, but its current status is unclear.

Study design
This study is interventional and plans to enroll 42 participants. It compares two treatments: Scaling and Root Planing (SRP) alone versus SRP with the addition of Arestin.
What's involved
You would receive either Scaling and Root Planing (SRP) alone or SRP with Arestin. Your gum pocket closure will be measured at the start, after 3 months, and after 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after treatment, with measurements taken at 3 and 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07298057

Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
Case Western Reserve University
~42 participants
Updated 2026-02-19 on ClinicalTrials.gov
What's tested:local antibiotic application of topical minocyclineScaling and Root Planing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pocket Closure
Measured over Baseline, 3 Months, 6 Months
Periodontitis, Diabetes Mellitus Type 2
1 sites across 1 states
Ohio1
  • Gian Pietro Schincaglia, DDS, PhD · PRINCIPAL_INVESTIGATOR · Case Western Reserve University

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  • Pocket ClosureBaseline, 3 Months, 6 Months

    Pocket Depth (PD ≤4 mm)