EXER-MED: Exercise and Tirzepatide for Weight and Health

This study, called EXER-MED, is looking at how exercise combined with a weight loss medication called tirzepatide affects weight and overall health. It aims to see if adding exercise helps more than just taking tirzepatide alone. You might be able to join if you are an adult between 30 and 65 years old and are considered overweight or have obesity. The study will measure your weight at the beginning and after 16 weeks to see the effects. Researchers also want to know if this combination improves other health factors like blood sugar, cholesterol, fitness, and quality of life. The study is currently unclear on its recruitment status.

Study design
This interventional study plans to enroll 24 participants to compare the effects of exercise plus tirzepatide versus tirzepatide alone.
What's involved
Participants will take tirzepatide for 16 weeks. If in the exercise group, you will exercise about 3 times a week at the University of Virginia for 16 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, weight, is measured at 16 weeks, suggesting follow-up for at least that duration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07298915

The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)

Not Yet Recruiting
PHASE3Ages 30–65InterventionalTreatment
University of Virginia
~24 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:TirzepatideExercise

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Weight
Measured over Baseline and 16 Weeks
Obesity & Overweight
1 sites across 1 states
Virginia1
  • Damon L Swift, Ph.D · PRINCIPAL_INVESTIGATOR · University of Virginia

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Eligibility criteria

Inclusion

Men and women 30-65 years of age, postmenopausal women included
27-29.9 with an additional CVD risk factor or 30-40 kg/m2
For overweight adults only: additional cardiometabolic risk factor (diagnosed dyslipidemia, hypertension)
Willingness and adequate health to go on weight loss medication
The capability and willingness to provide written informed consent
Approval of their primary care provider to go on weight loss medication

Exclusion

Including but not limited to serious arrhythmias
Cardiomyopathy
Congestive heart failure
Stroke or transient ischemic attacks
Peripheral vascular disease
Previous history of myocardial infarction or stroke
Previous diagnosis or taking medication for type 1 or 2 diabetes, fasting glucose \>125 mg/dL or HbA1C ≥6.5%
Systolic blood pressure \>160 mmHg and diastolic blood pressure \>100 mmHg.
Hospitalization for mental illness within the past 5 years or currently undergoing treatment for severe mental illness
Conditions that can be aggravated or are contraindicated by exercise training
Plans to be out of town more than 3 weeks in the next 4 months.
Currently pregnant or plans to become pregnant
Currently in a diet or exercise program
Non-compliance during screening or extreme difficulty in obtaining baseline blood samples
Enrolled in a different exercise program
Previous weight loss surgery
Use of weight loss medication within the last year
hypo/hyper thyroid (medicated or unmedicated)
  • WeightBaseline and 16 Weeks

    Measurement will be taken 3 times and measured in kg. A positive value indicates an increase in weight and a negative value indicates a reduction in weight