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DSLT for Normal Tension Glaucoma in Asian Patients

This study is looking at a laser treatment called Direct Selective Laser Trabeculoplasty (DSLT) for Asian patients with normal tension glaucoma (NTG). NTG is a type of glaucoma where eye pressure is normal but still damages the optic nerve. The DSLT device uses a non-contact laser to lower the pressure inside the eye (intraocular pressure or IOP). Researchers want to see if DSLT can reduce IOP and the need for glaucoma medications in Asian patients with NTG. You might be able to join if you are of Asian descent, are at least 20 years old, have an NTG diagnosis with specific vision field measurements, and are currently using 1-3 glaucoma medications. The main goal is to measure the change in your eye pressure 12 months after the procedure.

Study design
This is an interventional study planning to enroll 40 participants. The study type and phase are not specified.
What's involved
Participants will have routine follow-up visits with their eye surgeon and undergo glaucoma tests like OCT imaging and visual field tests after the laser treatment.
Compensation
Not stated in the trial record.
Follow-up
Your eye pressure will be measured 12 months after the procedure to see the long-term effects.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07300852

DSLT in Normal Tension Glaucoma (NTG) Asian Eyes

Not Yet Recruiting
NAAges 20+InterventionalTreatment
Ngoc Nguyen Inc.
~40 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:Direct Selective Laser Trabeculoplasty (DSLT)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Intraocular Pressure (IOP)
Measured over 12 months post procedure

Conditions

Normal Tension Glaucoma (NTG)
Glaucoma
Open Angle Glaucoma (OAG)
Glaucoma, Open Angle

Explore related trials

Low tension glaucoma

Where it's being run

1 sites across 1 states
California1

Who to contact

Ngoc Nguyen, M.D.
[email protected]
4082723706
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Asian descent
NTG diagnosis: glaucomatous optic neuropathy in patients with IOP measurements consistently lower than 21 mmHg
Mean deviation (MD) of the visual field between 0 to -12dB
No significant central vision loss within 5 degrees within 5th percentile
Age ≥20 years
NTG patients who are medically controlled on 1-3 medications and safe to wash out or IOP is still insufficient from medications and safe to washout
Shaffer grade II or more on 3 of the 4 quadrants
Central corneal thickness (CCT) 450-600µm
All participants are able to provide written informed consent before participation

Exclusion

Angle closure glaucoma or narrow angle status post laser peripheral iridotomy (LPI), or any other open angle glaucoma excluding NTG
History of SLT within last 2 years
History intraocular surgery including refractive surgery, except for history of cataract surgery that has been greater than 1 year
Patients anticipating cataract surgery during the study follow-up period
Unable to have DSLT procedure due to pre-limbal findings
Any presence of relevant ocular diseases including retinal disease with no confirmed cure

What this trial measures

  • Change in Intraocular Pressure (IOP)12 months post procedure

    Absolute change in washed-out intraocular pressure (IOP) at 12 months compared to washed-out baseline IOP. Following a 6-week washout at baseline and again at month 11, IOP will be measured using standard tonometry to assess the effect of Direct Selective Laser Trabeculoplasty (DSLT) on pressure reduction.