This study is looking at how two hormones, insulin and glucagon, work together in the liver to control blood sugar. Researchers are trying to understand new ways glucagon affects the body, which could lead to better treatments for diabetes. You might be able to join if you are a healthy adult between 18 and 45 years old, with a BMI (Body Mass Index) under 27.0 kg/m², and normal blood sugar levels. Participants will receive either glucagon (a drug) or saline (a placebo, or inactive substance) through an IV while blood sugar is carefully monitored. The main goal is to see if insulin and glucagon working together can improve how sensitive the liver is to insulin. The current status of this study is unclear, and it plans to enroll 40 people.

Study design

This is an interventional study involving 40 participants. It uses a hyperinsulinemic glucose clamp procedure where participants receive either glucagon or saline.

What's involved

You would undergo screening, and if eligible, participate in two or four 5-hour visits where you receive IV infusions and have blood samples taken. The study participation will last approximately 5-12 weeks.

Compensation

Not stated in the trial record.

Follow-up

Outcomes will be measured during the final 90 minutes of the hyperinsulinemic glucose clamp procedure and at specific time points during the visits.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.